Autoimmune heparin‐induced thrombocytopenia (aHIT) indicates the presence in patients of
anti‐platelet factor 4 (PF4)–polyanion antibodies that are able to activate platelets strongly …

The antiphospholipid syndrome is a prothrombotic disorder associated with autoantibodies.
It is associated with obstetrical complications (mainly spontaneous abortion) as well as …

Gram-negative bacteria decorate their outermost surface structure, lipopolysaccharide, with
elaborate chemical moieties, which effectively disguises them from immune surveillance and …

Objective Antiphospholipid antibodies (aPL), especially those targeting β2‐glycoprotein I
(β2GPI), are well known to activate endothelial cells, monocytes, and platelets, with …

1Oxford Haemophilia and Thrombosis Centre, Churchill Hospital, Oxford, UK, 2Haemostasis
Research Unit, Haematology Department, University College London, London, UK, 3Centre …

Antiphospholipid antibodies (aPL) are both diagnostic markers for, and pathogenic drivers
of, antiphospholipid syndrome (APS). Although the presence of aPL is a necessary pre …

Given the immense antigenic load present in the microbiome, we hypothesized that
microbiota mimotopes can be a persistent trigger in human autoimmunity via cross-reactivity …

Abstract Beta-2-Glycoprotein I (β2GPI) plays a number of essential roles throughout the
body. β2GPI, C-reactive protein and thrombomodulin are the only three proteins that …

Thrombotic antiphospholipid syndrome (APS) is characterised by venous, arterial and/or
small vessel thrombosis in the context of persistently positive antiphospholipid antibodies …

Summary β 2‐Glycoprotein I (β 2‐GPI) is a protein that circulates in blood at high
concentrations. The function of β 2‐GPI has long been an enigma. More than 20 years ago …