Multiple sclerosis and myelin basic protein: Insights into protein disorder and disease
V Martinsen, P Kursula - Amino Acids, 2022 - Springer
Myelin basic protein (MBP) is an abundant protein in central nervous system (CNS) myelin.
MBP has long been studied as a factor in the pathogenesis of the autoimmune …
MBP has long been studied as a factor in the pathogenesis of the autoimmune …
An online resource for GPCR structure determination and analysis
G-protein-coupled receptors (GPCRs) transduce physiological and sensory stimuli into
appropriate cellular responses and mediate the actions of one-third of drugs. GPCR …
appropriate cellular responses and mediate the actions of one-third of drugs. GPCR …
SoluProt: prediction of soluble protein expression in Escherichia coli
J Hon, M Marusiak, T Martinek, A Kunka… - …, 2021 - academic.oup.com
Motivation Poor protein solubility hinders the production of many therapeutic and industrially
useful proteins. Experimental efforts to increase solubility are plagued by low success rates …
useful proteins. Experimental efforts to increase solubility are plagued by low success rates …
LARMD: integration of bioinformatic resources to profile ligand-driven protein dynamics with a case on the activation of estrogen receptor
Protein dynamics is central to all biological processes, including signal transduction, cellular
regulation and biological catalysis. Among them, in-depth exploration of ligand-driven …
regulation and biological catalysis. Among them, in-depth exploration of ligand-driven …
Protein thermostability engineering
HP Modarres, MR Mofrad, A Sanati-Nezhad - RSC advances, 2016 - pubs.rsc.org
The use of enzymes for industrial and biomedical applications is limited to their function at
elevated temperatures. The principles of thermostability engineering need to be …
elevated temperatures. The principles of thermostability engineering need to be …
Aerobactin Seems To Be a Promising Marker Compared With Unstable RmpA2 for the Identification of Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae: In Silico …
Background The incidence of hypervirulent (hv) carbapenem-resistant (CR) Klebsiella
pneumoniae (Kp) is increasing globally among various clones and is also responsible for …
pneumoniae (Kp) is increasing globally among various clones and is also responsible for …
Identification of a drug targeting an intrinsically disordered protein involved in pancreatic adenocarcinoma
Intrinsically disordered proteins (IDPs) are prevalent in eukaryotes, performing signaling and
regulatory functions. Often associated with human diseases, they constitute drug …
regulatory functions. Often associated with human diseases, they constitute drug …
Multi-epitope vaccine for monkeypox using pan-genome and reverse vaccinology approaches
Outbreaks of monkeypox virus infections have imposed major health concerns worldwide,
with high morbidity threats to children and immunocompromised adults. Although …
with high morbidity threats to children and immunocompromised adults. Although …
SETH predicts nuances of residue disorder from protein embeddings
D Ilzhöfer, M Heinzinger, B Rost - Frontiers in Bioinformatics, 2022 - frontiersin.org
Predictions for millions of protein three-dimensional structures are only a few clicks away
since the release of AlphaFold2 results for UniProt. However, many proteins have so-called …
since the release of AlphaFold2 results for UniProt. However, many proteins have so-called …
Tripartite degrons confer diversity and specificity on regulated protein degradation in the ubiquitin-proteasome system
Specific signals (degrons) regulate protein turnover mediated by the ubiquitin-proteasome
system. Here we systematically analyse known degrons and propose a tripartite model …
system. Here we systematically analyse known degrons and propose a tripartite model …