With the increasing number of spaceflights, it is crucial to understand the changes occurring
in human cells exposed to real microgravity (r-µ g) conditions. We tested the effect of r-µ g on …

Background: Integrin family are known as key gears in focal adhesion for triple-negative
breast cancer (TNBC) metastasis. However, the integrin independent factor TLN1 remains …

Breast cancer is the most common malignant cancer in women worldwide. Cancer
metastasis is the major cause of cancer-related deaths. BCKDK is associated with various …

Colorectal cancer (CRC) remains the third most commonly diagnosed cancer, ranking
second among the most common causes of cancer‐related mortality. Immune checkpoint …

Phosphatidylinositol phosphate kinases (PIPKs) generate a lipid messenger
phosphatidylinositol 4, 5-bisphosphate (PI4, 5P 2) that controls essentially all aspects of …

Background Emerging evidence suggests that metabolic alterations are a hallmark of cancer
cells and contribute to tumor initiation and development. Cancer cells primarily utilize …

Type Iγ phosphatidylinositol phosphate kinase (PIPKIγ), a phospholipid kinase generating
PIP2, is positively expressed in breast cancer tissues, which correlates intimately with the …

Rationale: Oxaliplatin is a widely used chemotherapy drug for advanced colorectal cancer
(CRC) and its resistance is a major challenge for disease treatment. However, the molecular …

Background Talin-1 as a component of multi-protein adhesion complexes plays a role in
tumor formation and migration in various malignancies. This study investigated Talin-1 in …

Summary Phosphatidylinositol 3-kinase α (PI3Kα) is a heterodimer of p110α catalytic and
p85 adaptor subunits that is activated by agonist-stimulated receptor tyrosine kinases …