The use of 'Omics technology to rationally improve industrial mammalian cell line performance
AM Lewis, NR Abu‐Absi, MC Borys… - Biotechnology and …, 2016 - Wiley Online Library
Biologics represent an increasingly important class of therapeutics, with 7 of the 10 top
selling drugs from 2013 being in this class. Furthermore, health authority approval of …
selling drugs from 2013 being in this class. Furthermore, health authority approval of …
Host cell protein removal from biopharmaceutical preparations: Towards the implementation of quality by design
Downstream processing of protein products of mammalian cell culture currently accounts for
the largest fraction of the total production cost. A major challenge is the removal of host cell …
the largest fraction of the total production cost. A major challenge is the removal of host cell …
High quality genome sequences of thirteen Hypoxylaceae (Ascomycota) strengthen the phylogenetic family backbone and enable the discovery of new taxa
Abstract The Hypoxylaceae (Xylariales, Ascomycota) is a diverse family of mainly
saprotrophic fungi, which commonly occur in angiosperm-dominated forests around the …
saprotrophic fungi, which commonly occur in angiosperm-dominated forests around the …
Genome analysis of the sugar beet pathogen Rhizoctonia solani AG2-2IIIB revealed high numbers in secreted proteins and cell wall degrading enzymes
Abstract Background Sugar beet (Beta vulgaris) is a crop cultivated for its high content in
sugar, but it is vulnerable to many soil-borne pathogens. One of them is the basidiomycete …
sugar, but it is vulnerable to many soil-borne pathogens. One of them is the basidiomycete …
Three previously unrecognised classes of biosynthetic enzymes revealed during the production of xenovulene A
Xenovulene A is a complex fungal meroterpenoid, produced by the organism hitherto known
as Acremonium strictum IMI 501407, for which limited biosynthetic evidence exists. Here, we …
as Acremonium strictum IMI 501407, for which limited biosynthetic evidence exists. Here, we …
Effect of temperature downshift on the transcriptomic responses of Chinese hamster ovary cells using recombinant human tissue plasminogen activator production …
Recombinant proteins are widely used as biopharmaceuticals, but their production by
mammalian cell culture is expensive. Hence, improvement of bioprocess productivity is …
mammalian cell culture is expensive. Hence, improvement of bioprocess productivity is …
Transcriptional Changes in Potato Sprouts upon Interaction with Rhizoctonia solani Indicate Pathogen-Induced Interference in the Defence Pathways of Potato
Rhizoctonia solani is the causer of black scurf disease on potatoes and is responsible for
high economical losses in global agriculture. In order to increase the limited knowledge of …
high economical losses in global agriculture. In order to increase the limited knowledge of …
A novel plant-fungal association reveals fundamental sRNA and gene expression reprogramming at the onset of symbiosis
Beneficial associations between plants and microbes are widespread in nature and have
been studied extensively in the microbial-dominant environment of the rhizosphere. Such …
been studied extensively in the microbial-dominant environment of the rhizosphere. Such …
The sporothriolides. A new biosynthetic family of fungal secondary metabolites
The biosynthetic gene cluster of the antifungal metabolite sporothriolide 1 was identified
from three producing ascomycetes: Hypomontagnella monticulosa MUCL 54604, H …
from three producing ascomycetes: Hypomontagnella monticulosa MUCL 54604, H …
Linking secondary metabolites to biosynthesis genes in the fungal endophyte Cyanodermella asteris: The anti-cancer bisanthraquinone skyrin
L Jahn, T Schafhauser, D Wibberg, C Rueckert… - Journal of …, 2017 - Elsevier
Fungal aromatic polyketides display a very diverse and widespread group of natural
products. Due to their excellent light absorption properties and widely studied biological …
products. Due to their excellent light absorption properties and widely studied biological …