Residual dipolar couplings as a tool in determining the structure of organic molecules

G Kummerlöwe, B Luy - TrAC Trends in Analytical Chemistry, 2009 - Elsevier
In the past decade, residual dipolar couplings (RDCs) have revolutionized biomolecular
nuclear magnetic resonance spectroscopy. Recent developments indicate that this …

Residual dipolar couplings (RDCs) in organic structure determination

CM Thiele - European Journal of Organic Chemistry, 2008 - Wiley Online Library
After the huge impact that residual dipolar couplings (RDCs) have had on the structure
determination of biological macromolecules by NMR spectroscopy, their utility in the …

The CLIP/CLAP-HSQC: pure absorptive spectra for the measurement of one-bond couplings

A Enthart, JC Freudenberger, J Furrer, H Kessler… - Journal of Magnetic …, 2008 - Elsevier
Heteronuclear residual dipolar one-bond couplings of organic molecules at natural
abundance are most easily measured using t2 coupled HSQC spectra. However, inevitably …

Residual dipolar couplings for the configurational and conformational analysis of organic molecules

G Kummerlöwe, B Luy - Annual reports on NMR spectroscopy, 2009 - Elsevier
Residual dipolar couplings (RDCs) have already revolutionized biomolecular NMR
spectroscopy and are about to do the same in small molecule applications: impressive …

Speeding up the measurement of one-bond scalar (1J) and residual dipolar couplings (1D) by using non-uniform sampling (NUS)

CM Thiele, W Bermel - Journal of Magnetic Resonance, 2012 - Elsevier
The accurate and precise measurement of one-bond scalar and residual dipolar coupling
(RDC) constants is of prime importance to be able to use RDCs for structure determination. If …

Homonuclear BIRD-decoupled spectra for measuring one-bond couplings with highest resolution: CLIP/CLAP-RESET and constant-time-CLIP/CLAP-RESET

T Reinsperger, B Luy - Journal of Magnetic Resonance, 2014 - Elsevier
Heteronuclear one-bond couplings are of interest for various aspects of structural analysis of
small organic molecules, including for example the distinction of axial and equatorial …

PE HSQC: A simple experiment for simultaneous and sign-sensitive measurement of (1JCH+ DCH) and (2JHH+ DHH) couplings

P Tzvetkova, S Simova, B Luy - Journal of Magnetic Resonance, 2007 - Elsevier
The angular information content of residual dipolar couplings between nuclei of fixed
distance makes the accurate and sign-sensitive measurement of (1JCH+ DCH) and (2JHH+ …

IPAP–HSQMBC: Measurement of long-range heteronuclear coupling constants from spin-state selective multiplets

S Gil, JF Espinosa, T Parella - Journal of Magnetic Resonance, 2010 - Elsevier
A new NMR approach is proposed for the measurement of long-range heteronuclear
coupling constants (nJXH, n> 1) in natural abundance molecules. Two complementary in …

[HTML][HTML] Trichophycin A, a Cytotoxic Linear Polyketide Isolated from a Trichodesmium thiebautii Bloom

MJ Bertin, PG Wahome, PV Zimba, H He, PDR Moeller - Marine Drugs, 2017 - mdpi.com
In an effort to isolate and characterize bioactive secondary metabolites from Trichodesmium
thiebautii blooms, collected cyanobacteria biomass was subjected to bioassay-guided …

Accurate measurement of small heteronuclear coupling constants from pure-phase α/β HSQMBC cross-peaks

S Gil, JF Espinosa, T Parella - Journal of Magnetic Resonance, 2011 - Elsevier
A simple proton-selective α/β-HSQMBC experiment is proposed for the accurate
measurement of long-range proton–carbon coupling constants (nJCH) in small molecules …