The serine/threonine kinase CHK2 is a key component of the DNA damage response. In
human cells, following genotoxic stress, CHK2 is activated and phosphorylates> 20 proteins …

Well before the gene (ATM) mutated in the human genetic disorder ataxia-telangiectasia
(AT) was described it was evident from the clinical, molecular and cellular phenotype of AT …

In the past decade, CHK2 has emerged as an important multifunctional player in the DNA-
damage response signalling pathway. Parallel studies of the human CHEK2 gene have also …

In eukaryotes, fumarase (FH in human) is a well-known tricarboxylic-acid-cycle enzyme in
the mitochondrial matrix. However, conserved from yeast to humans is a cytosolic …

In HPV–related cancers, the “high-risk” human papillomaviruses (HPVs) are frequently
found integrated into the cellular genome. The integrated subgenomic HPV fragments …

We have previously demonstrated that the human papillomavirus (HPV) genome replicates
effectively in U2OS cells after transfection using electroporation. The transient …

A novel class of small non-coding RNAs called DNA damage response RNAs (DDRNAs)
generated at DNA double-strand breaks (DSBs) in a DROSHA-and DICER-dependent …

Proteasome inhibitors are novel antitumor agents against multiple myeloma and other
malignancies. Despite the increasing clinical application, the molecular basis of their …

The cellular response to DNA damage is a crucial surveillance mechanism that maintains
genomic integrity and prevents cancer progression. Previous studies identified multiple …

There is an intricate balance of DNA damage response and repair which determines the
homeostasis of human genome function. p53 protein is widely known for its role in cell cycle …