Bacterial type III secretion systems: a complex device for the delivery of bacterial effector proteins into eukaryotic host cells

S Wagner, I Grin, S Malmsheimer… - FEMS microbiology …, 2018 - academic.oup.com
Virulence-associated type III secretion systems (T3SS) serve the injection of bacterial
effector proteins into eukaryotic host cells. They are able to secrete a great diversity of …

Type III secretion: building and operating a remarkable nanomachine

AG Portaliou, KC Tsolis, MS Loos, V Zorzini… - Trends in biochemical …, 2016 - cell.com
The Type III secretion system (T3SS) is a protein export pathway that is widespread in Gram-
negative bacteria and delivers effector proteins directly into eukaryotic cells. At its core lie …

Visualization of the type III secretion mediated Salmonella–host cell interface using cryo-electron tomography

D Park, M Lara-Tejero, MN Waxham, W Li, B Hu… - Elife, 2018 - elifesciences.org
Many important gram-negative bacterial pathogens use highly sophisticated type III protein
secretion systems (T3SSs) to establish complex host-pathogen interactions. Bacterial-host …

The structure and function of type III secretion systems

RQ Notti, CE Stebbins - Virulence mechanisms of bacterial …, 2016 - Wiley Online Library
Type III secretion systems (T3SSs) afford Gram‐negative bacteria an intimate means of
altering the biology of their eukaryotic hosts—the direct delivery of effector proteins from the …

[HTML][HTML] The Shigella type III secretion system: an overview from top to bottom

M Muthuramalingam, SK Whittier, WL Picking… - Microorganisms, 2021 - mdpi.com
Shigella comprises four species of human-restricted pathogens causing bacillary dysentery.
While Shigella possesses multiple genetic loci contributing to virulence, a type III secretion …

The type III secretion system needle, tip, and translocon

S Dey, A Chakravarty, P Guha Biswas… - Protein …, 2019 - Wiley Online Library
Many Gram‐negative bacteria pathogenic to plants and animals deploy the type III secretion
system (T3SS) to inject virulence factors into their hosts. All bacteria that rely on the T3SS to …

The T3SS of Shigella: Expression, Structure, Function, and Role in Vacuole Escape

W Bajunaid, N Haidar-Ahmad, AH Kottarampatel… - Microorganisms, 2020 - mdpi.com
Shigella spp. are one of the leading causes of infectious diarrheal diseases. They are
Escherichia coli pathovars that are characterized by the harboring of a large plasmid that …

The injectisome, a complex nanomachine for protein injection into mammalian cells

M Lara-Tejero, JE Galán - EcoSal Plus, 2019 - Am Soc Microbiol
Type III protein secretion systems (T3SSs), or injectisomes, are multiprotein nanomachines
present in many Gram-negative bacteria that have a sustained long-standing close …

An elegant nano-injection machinery for sabotaging the host: Role of Type III secretion system in virulence of different human and animal pathogenic bacteria

D Hajra, AV Nair, D Chakravortty - Physics of life Reviews, 2021 - Elsevier
Various Gram-negative bacteria possess a specialized membrane-bound protein secretion
system known as the Type III secretion system (T3SS), which transports the bacterial effector …

[HTML][HTML] Cryo-EM of the injectisome and type III secretion systems

JRC Bergeron, TC Marlovits - Current Opinion in Structural Biology, 2022 - Elsevier
Double-membrane-spanning protein complexes, such as the T3SS, had long presented an
intractable challenge for structural biology. As a consequence, until a few years ago, our …