Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …

The unique two-photon excitable luminescence and dual-emission ratio output features
endow organic molecule-based ratiometric two-photon fluorescence (RTPF) probes as …

The complex mTORC2 is accepted to be the kinase that controls the phosphorylation of the
hydrophobic motif, a key regulatory switch for AGC kinases, although whether mTOR directly …

Genetically encoded fluorescent biosensors have revolutionized the study of cell signaling
and metabolism, as they allow for live-cell measurements with high spatiotemporal …

Genetically-encoded biosensors based on a single fluorescent protein are widely used to
visualize analyte levels or enzymatic activities in cells, though usually to monitor relative …

Genetically encoded Förster Resonance Energy Transfer (FRET)-based biosensors are
powerful tools to illuminate spatiotemporal regulation of cell signaling in living cells, but the …

Cell signaling networks are intricately regulated in time and space to determine the
responses and fates of cells to different cues. Genetically encodable fluorescent and …

Fluorescence resonance energy transfer (FRET) has become a powerful tool for visualizing
molecular interactions, single-molecule conformational dynamics, binding, and other …

AURKA is a serine/threonine kinase overexpressed in several cancers. Originally identified
as a protein with multifaceted roles during mitosis, improvements in quantitative microscopy …

Cyclic adenosine monophosphate (cAMP) is a universal second messenger that plays a
crucial role in diverse biological functions, ranging from transcription to neuronal plasticity …