Trypanosoma cruzi genetic diversity: Something new for something known about Chagas disease manifestations, serodiagnosis and drug sensitivity
B Zingales - Acta tropica, 2018 - Elsevier
The genetic diversity of Trypanosoma cruzi, the protozoan agent of Chagas disease, is
widely recognized. At present, T. cruzi is partitioned into seven discrete typing units (DTUs) …
widely recognized. At present, T. cruzi is partitioned into seven discrete typing units (DTUs) …
[HTML][HTML] Advances in the treatment of Chagas disease: Promising new drugs, plants and targets
P García-Huertas, N Cardona-Castro - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Chagas disease, caused by Trypanosoma cruzi, is treated with only two drugs;
benznidazole and nifurtimox. These drugs have some disadvantages, including their …
benznidazole and nifurtimox. These drugs have some disadvantages, including their …
Current drug therapy and pharmaceutical challenges for Chagas disease
One of the most significant health problems in the American continent in terms of human
health, and socioeconomic impact is Chagas disease, caused by the protozoan parasite …
health, and socioeconomic impact is Chagas disease, caused by the protozoan parasite …
Review on Experimental Treatment Strategies Against Trypanosoma cruzi
AL Mazzeti, P Capelari-Oliveira, MT Bahia… - Journal of …, 2021 - Taylor & Francis
Chagas disease is a neglected tropical disease caused by the protozoan Trypanosoma
cruzi. Currently, only nitroheterocyclic nifurtimox (NFX) and benznidazole (BNZ) are …
cruzi. Currently, only nitroheterocyclic nifurtimox (NFX) and benznidazole (BNZ) are …
The current drug discovery landscape for trypanosomiasis and leishmaniasis: Challenges and strategies to identify drug targets
F Altamura, R Rajesh, CMC Catta‐Preta… - Drug development …, 2022 - Wiley Online Library
Human trypanosomiasis and leishmaniasis are vector‐borne neglected tropical diseases
caused by infection with the protozoan parasites Trypanosoma spp. and Leishmania spp …
caused by infection with the protozoan parasites Trypanosoma spp. and Leishmania spp …
Chagas disease diagnostic applications: present knowledge and future steps
V Balouz, F Agüero, CA Buscaglia - Advances in parasitology, 2017 - Elsevier
Chagas disease, caused by the protozoan Trypanosoma cruzi, is a lifelong and debilitating
illness of major significance throughout Latin America and an emergent threat to global …
illness of major significance throughout Latin America and an emergent threat to global …
[HTML][HTML] Fexinidazole: a potential new drug candidate for Chagas disease
MT Bahia, IM Andrade, TAF Martins… - PLoS neglected …, 2012 - journals.plos.org
Background New safe and effective treatments for Chagas disease (CD) are urgently
needed. Current chemotherapy options for CD have significant limitations, including failure …
needed. Current chemotherapy options for CD have significant limitations, including failure …
[HTML][HTML] Development of Trypanosoma cruzi in vitro assays to identify compounds suitable for progression in Chagas' disease drug discovery
LM MacLean, J Thomas, MD Lewis… - PLoS neglected …, 2018 - journals.plos.org
Chagas' disease is responsible for significant mortality and morbidity in Latin America.
Current treatments display variable efficacy and have adverse side effects, hence more …
Current treatments display variable efficacy and have adverse side effects, hence more …
[HTML][HTML] Benznidazole and posaconazole in experimental Chagas disease: positive interaction in concomitant and sequential treatments
Background Current chemotherapy for Chagas disease is unsatisfactory due to its limited
efficacy, particularly in the chronic phase, with frequent side effects that can lead to treatment …
efficacy, particularly in the chronic phase, with frequent side effects that can lead to treatment …
Natural products and Chagas' disease: a review of plant compounds studied for activity against Trypanosoma cruzi
E Izumi, T Ueda-Nakamura, BP Dias Filho… - Natural Product …, 2011 - pubs.rsc.org
Covering: 1995 to 2010 Here, we review studies that have investigated the activity of plant-
derived compounds against Trypanosoma cruzi, the etiologic agent of Chagas' disease. In …
derived compounds against Trypanosoma cruzi, the etiologic agent of Chagas' disease. In …