Three-way junction skeleton biosensors based on aptamers, DNAzymes, and DNA hybridization probes

H Zahraee, Z Khoshbin, F Mohammadi… - TrAC Trends in …, 2023 - Elsevier
Nucleic acids can be used as building blocks for highly regular and complex structures at
the nanoscale due to their inherent self-assembly and programmability resulting from intra …

A modular aldol approach for internal fluorescent molecular rotor chalcone surrogates for DNA biosensing applications

RE Johnson, MT Murray, LJ Bycraft, SD Wetmore… - Chemical …, 2023 - pubs.rsc.org
Fluorescent molecular rotors (FMRs) are critical tools for probing nucleic acid structure and
function. Many valuable FMRs have been incorporated into oligonucleotides, although the …

Redox Reporter‐Ligand Competition to Support Signaling in the Cocaine‐Binding Electrochemical Aptamer‐Based Biosensor

P Dauphin‐Ducharme, ZR Churcher… - … A European Journal, 2023 - Wiley Online Library
Electrochemical aptamer‐based (E‐AB) biosensors have demonstrated capabilities in
monitoring molecules directly in undiluted complex matrices and in the body with the hopes …

Solution and Gas-Phase Stability of DNA Junctions from Temperature-Controlled Electrospray Ionization and Surface-Induced Dissociation

A Pruška, JA Harrison, A Granzhan… - Analytical …, 2023 - ACS Publications
DNA three-way junction (TWJ) structures transiently form during key cellular processes such
as transcription, replication, and DNA repair. Despite their significance, the thermodynamics …

DNA binding by the antimalarial compound artemisinin

S Slavkovic, AA Shoara, ZR Churcher, E Daems… - Scientific reports, 2022 - nature.com
Artemisinin (ART) is a vital medicinal compound that is used alone or as part of a
combination therapy against malaria. ART is thought to function by attaching to heme …

An ultrasensitive liquid crystal aptasensing chip assisted by three-way junction DNA pockets for acrylamide detection in food samples

Z Khoshbin, F Mohammadi, M Moeenfard… - Journal of Hazardous …, 2024 - Elsevier
Acrylamide, an unsaturated amide found in heat-processed foods, poses serious risks to
human health due to its neurotoxicity, carcinogenicity, and genotoxicity. This highlights the …

Thieno[3,2-b]thiophene for the Construction of Far-Red Molecular Rotor Hemicyanines as High-Affinity DNA Aptamer Fluorogenic Reporters

RE Johnson, A Pounder, J van der Zalm… - Analytical …, 2024 - ACS Publications
The construction of far-red fluorescent molecular rotors (FMRs) is an imperative task for
developing nucleic acid stains that have superior compatibility with cellular systems and …

Tuning the DNA binding properties of phenolic hemicyanine dyes for host-guest fluorescent aptasensor applications

AJ Van Riesen, B Kalnitsky, AA Shoara, S Slavkovic… - Dyes and …, 2023 - Elsevier
Fluorescent dyes that bind specifically to DNA aptamers with turn-on emission serve as
powerful tools for biosensor development. DNA three-way junctions (3WJs) consisting of a Y …

Fluorogenic target competitors for developing label-free and sensitive folding-unswitching aptamer sensors

X Zeng, X Tong, J Chen, Q Chen, R Lai, Q Xu… - Analytica Chimica …, 2024 - Elsevier
Background Aptamers have aroused tremendous applications in sensors, drug deliveries,
diagnosis, and therapies. In particular, target-induced global structure switching of aptamers …

Amodiaquine Nonspecifically Binds Double Stranded and Three‐Way Junction DNA Structures

S Slavkovic, AA Shoara, YA Kaiyum… - …, 2024 - Wiley Online Library
The 4‐aminoquinoline class of compounds includes the important antimalarial compounds
amodiaquine and chloroquine. Despite their medicinal importance, the mode of action of …