Background The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad
pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose …

Chronic activation of the renin‐angiotensin‐aldosterone system (RAAS) promotes and
perpetuates the syndromes of congestive heart failure, systemic hypertension, and chronic …

Although intrinsic mechanisms that regulate arterial blood pressure (BP) are similar in men
and women, marked variations exist at the molecular, cellular and tissue levels. These …

Background Sodium-glucose cotransporter-2 inhibitors reduce blood pressure (BP) and
renal and cardiovascular events in patients with type 2 diabetes through not fully elucidated …

Aims Renal inflammation, leading to fibrosis and impaired function is a major contributor to
the development of hypertension. The NLRP3 inflammasome mediates inflammation in …

Baroreflex Dysfunction Baroreflexes play both an adaptive and a homeostatic role,
maintaining blood pressure, heart rate, and blood volume within the normal range. Defects …

Compared with males, females have lower BP before age 60, blunted hypertensive
response to angiotensin II, and a leftward shift in pressure natriuresis. This study tested the …

Mammalian kidneys are specialized to maintain fluid and electrolyte homeostasis. The
epithelial transport processes along the renal tubule that match output to input have long …

Key differences exist between men and women in the determinants and manifestations of
cardiovascular and cardiometabolic diseases. Recently, gut microbiome-host relations have …

The role of salt in the pathogenesis of arterial hypertension is not well understood.
According to the current understanding, the central mechanism for blood pressure (BP) …