Drug addiction represents a dramatic dysregulation of motivational circuits that is caused by
a combination of exaggerated incentive salience and habit formation, reward deficits and …

Feeding provides substrate for energy metabolism, which is vital to the survival of every
living animal and therefore is subject to intense regulation by brain homeostatic and hedonic …

Of the many conceptual distinctions present in psychology today, the approach-avoidance
distinction stands out as one of, if not the, most fundamental and basic. The distinction …

The natural incentives that shape behavior reach the central circuitry of motivation trans-
synaptically, via the five senses, whereas the laboratory rewards of intracranial stimulation …

Drug Addiction | New England Journal of Medicine Skip to main content The New England
Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES Cardiology …

▪ Abstract G protein–coupled receptors (GPCRs) have proven to be the most highly
favorable class of drug targets in modern pharmacology. Over 90% of nonsensory GPCRs …

Substance use disorders (SUDs) manifest as chronic relapsing disorders, characterized by
compulsive drug taking despite serious adverse consequences, the loss of control over …

Drug addiction manifests as a compulsive drive to take a drug despite serious adverse
consequences. This aberrant behaviour has traditionally been viewed as bad'choices' that …

Imaging studies have provided evidence of how the human brain changes as an individual
becomes addicted. Here, we integrate the findings from imaging studies to propose a model …

What is the role of dopamine in natural rewards? A genetic mutant approach was taken to
examine the consequences of elevated synaptic dopamine on (1) spontaneous food and …