m6A modification: recent advances, anticancer targeted drug discovery and beyond

LJ Deng, WQ Deng, SR Fan, MF Chen, M Qi, WY Lyu… - Molecular cancer, 2022 - Springer
Abstract Abnormal N6-methyladenosine (m6A) modification is closely associated with the
occurrence, development, progression and prognosis of cancer, and aberrant m6A …

NBR1: The archetypal selective autophagy receptor

NL Rasmussen, A Kournoutis, T Lamark… - Journal of Cell …, 2022 - rupress.org
NBR1 was discovered as an autophagy receptor not long after the first described vertebrate
autophagy receptor p62/SQSTM1. Since then, p62 has currently been mentioned in> 10,000 …

METTL14 is required for exercise-induced cardiac hypertrophy and protects against myocardial ischemia-reperfusion injury

L Wang, J Wang, P Yu, J Feng, G Xu, X Zhao… - Nature …, 2022 - nature.com
RNA m6A modification is the most widely distributed RNA methylation and is closely related
to various pathophysiological processes. Although the benefit of regular exercise on the …

Methyltransferase-like proteins in cancer biology and potential therapeutic targeting

YN Qi, Z Liu, LL Hong, P Li, ZQ Ling - Journal of Hematology & Oncology, 2023 - Springer
RNA modification has recently become a significant process of gene regulation, and the
methyltransferase-like (METTL) family of proteins plays a critical role in RNA modification …

RNA-binding proteins in regulating mRNA stability and translation: roles and mechanisms in cancer

W Li, X Deng, J Chen - Seminars in cancer biology, 2022 - Elsevier
ABSTRACT RNA-binding proteins (RBPs) are key players in cellular physiology through
posttranscriptional regulation of the expression of target RNA transcripts. By modulating the …

[HTML][HTML] The role of Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) as m6A readers in cancer

CY Sun, D Cao, BB Du, CW Chen… - International Journal of …, 2022 - ncbi.nlm.nih.gov
RNA can be modified by over 170 types of distinct chemical modifications, and the most
abundant internal modification of mRNA in eukaryotes is N6-methyladenosine (m 6 A). The …

Roles of RNA modifications in diverse cellular functions

E Wilkinson, YH Cui, YY He - Frontiers in Cell and Developmental …, 2022 - frontiersin.org
Chemical modifications of RNA molecules regulate both RNA metabolism and fate. The
deposition and function of these modifications are mediated by the actions of writer, reader …

METTL3 protects METTL14 from STUB1‐mediated degradation to maintain m6A homeostasis

ZC Zeng, Q Pan, YM Sun, HJ Huang, XT Chen… - EMBO …, 2023 - embopress.org
Abstract N 6‐Methyladenosine (m6A) is an important RNA modification catalyzed by
methyltransferase‐like 3 (METTL3) and METTL14. m6A homeostasis mediated by the …

METTL14 promotes prostate tumorigenesis by inhibiting THBS1 via an m6A-YTHDF2-dependent mechanism

Y Wang, J Chen, WQ Gao, R Yang - Cell death discovery, 2022 - nature.com
Abstract N6-methyladenine (m6A) is the most predominant RNA modification, which has
been shown to be related to many types of cancers. However, understanding of its role in …

METTL14 modulates glycolysis to inhibit colorectal tumorigenesis in p53‐wild‐type cells

Y Hou, X Zhang, H Yao, L Hou, Q Zhang, E Tao… - EMBO …, 2023 - embopress.org
The frequency of p53 mutations in colorectal cancer (CRC) is approximately 40–50%. A
variety of therapies are being developed to target tumors expressing mutant p53. However …