The tissue-engineered vascular graft—past, present, and future

S Pashneh-Tala, S MacNeil… - Tissue Engineering Part B …, 2016 - liebertpub.com
Cardiovascular disease is the leading cause of death worldwide, with this trend predicted to
continue for the foreseeable future. Common disorders are associated with the stenosis or …

Bioengineered human blood vessels

LE Niklason, JH Lawson - Science, 2020 - science.org
BACKGROUND Vascular replacement and repair for the treatment of atherosclerotic
disease, infection, and traumatic injury are some of the most commonly performed surgical …

Current strategies for the manufacture of small size tissue engineering vascular grafts

M Carrabba, P Madeddu - Frontiers in bioengineering and …, 2018 - frontiersin.org
Occlusive arterial disease, including coronary heart disease (CHD) and peripheral arterial
disease (PAD), is the main cause of death, with an annual mortality incidence predicted to …

Fibrin: a versatile scaffold for tissue engineering applications

TAE Ahmed, EV Dare, M Hincke - Tissue Engineering Part B …, 2008 - liebertpub.com
Tissue engineering combines cell and molecular biology with materials and mechanical
engineering to replace damaged or diseased organs and tissues. Fibrin is a critical blood …

Mechanical properties of completely autologous human tissue engineered blood vessels compared to human saphenous vein and mammary artery

G Konig, TN McAllister, N Dusserre, SA Garrido… - Biomaterials, 2009 - Elsevier
We have previously reported the initial clinical feasibility with our small diameter tissue
engineered blood vessel (TEBV). Here we present in vitro results of the mechanical …

Molecular regulation of contractile smooth muscle cell phenotype: implications for vascular tissue engineering

JA Beamish, P He, K Kottke-Marchant… - … Engineering Part B …, 2010 - liebertpub.com
The molecular regulation of smooth muscle cell (SMC) behavior is reviewed, with particular
emphasis on stimuli that promote the contractile phenotype. SMCs can shift reversibly along …

A review of cellularization strategies for tissue engineering of whole organs

ME Scarritt, NC Pashos, BA Bunnell - Frontiers in bioengineering and …, 2015 - frontiersin.org
With the advent of whole organ decellularization, extracellular matrix scaffolds suitable for
organ engineering were generated from numerous tissues, including the heart, lung, liver …

Future perspectives in small-diameter vascular graft engineering

P Mallis, A Kostakis, C Stavropoulos-Giokas… - Bioengineering, 2020 - mdpi.com
The increased demands of small-diameter vascular grafts (SDVGs) globally has forced the
scientific society to explore alternative strategies utilizing the tissue engineering …

Substrates for cardiovascular tissue engineering

CVC Bouten, PYW Dankers, A Driessen-Mol… - Advanced drug delivery …, 2011 - Elsevier
Cardiovascular tissue engineering aims to find solutions for the suboptimal regeneration of
heart valves, arteries and myocardium by creating 'living'tissue replacements outside (in …

Considerations in the development of small-diameter vascular graft as an alternative for bypass and reconstructive surgeries: a review

FO Obiweluozor, GA Emechebe, DW Kim… - Cardiovascular …, 2020 - Springer
Background Current design strategies for small diameter vascular grafts (< 6 mm internal
diameter; ID) are focused on mimicking native vascular tissue because the commercially …