Since its first observation in 1907, ortho-quinone methide (o-QM) has occupied a strategic
place within the framework of reactive intermediates in organic synthesis. In recent years, o …

Anthracycline antibiotics are among the most effective and commonly used anticancer
drugs. Unfortunately, their clinical use is restricted by dose-dependent toxicity. Doxorubicin …

The combination of doxorubicin (Adriamycin) and cyclophosphamide, referred to as AC
chemotherapy, is commonly used for the clinical treatment of breast and other cancers. Both …

The importance of reactive drug metabolites in the pathogenesis of drug-induced toxicity has
been investigated since the early 1950s, mainly to reveal the link between toxic metabolites …

Targeted cancer treatment should avoid side effects and damage to healthy cells commonly
encountered during traditional chemotherapy. By combining small molecule or peptidic …

Doxorubicin has been in use as a key anticancer drug for forty years, either as a single
agent or in combination chemotherapy. It functions primarily by interfering with …

Excitation of 2-hydroxy-3-(diphenylhydroxymethyl) anthracene (7) to S1 initiates
photodehydration, giving the corresponding quinone methide (QM) that was detected by …

Abstract The 1-[(pyridin-2-yl amino) methyl] pyrrolidine-2, 5-dione (SFAP) is a class of
organic Mannich base system which has been identified for its effective performance in favor …

Cardiotoxicity is a serious complication of anticancer therapy by anthracycline antibiotics.
Except for intercalation into DNA/RNA structure, inhibition of DNA-topoisomerase and …

A Mannich base molecule of 2-(piperidin-1-ylmethyl) isoindoline-1, 3-dione (PPF) has been
synthesized using Mannich base condensation reaction. The molecular geometry of PPF …