[HTML][HTML] Metabolomics in Pulmonary Hypertension—A Useful Tool to Provide Insights into the Dark Side of a Tricky Pathology

PP Bassareo, M D'Alto - International Journal of Molecular Sciences, 2023 - mdpi.com
Pulmonary hypertension (PH) is a multifaceted illness causing clinical manifestations like
dyspnea, fatigue, and cyanosis. If left untreated, it often evolves into irreversible pulmonary …

Application of Metabolomics across the Spectrum of Pulmonary and Critical Care Medicine

CE Simpson, JG Ledford, G Liu - American journal of respiratory cell …, 2024 - atsjournals.org
In recent years, metabolomics, the systematic study of small-molecule metabolites in
biological samples, has yielded fresh insights into the molecular determinants of pulmonary …

Spatial and temporal resolution of metabolic dysregulation in the Sugen hypoxia model of pulmonary hypertension

CE Simpson, AS Ambade, R Harlan… - Pulmonary …, 2023 - Wiley Online Library
Although PAH is partially attributed to disordered metabolism, previous human studies have
mostly examined circulating metabolites at a single time point, potentially overlooking crucial …

Fatty acid metabolism promotes TRPV4 activity in lung microvascular endothelial cells in pulmonary arterial hypertension

N Philip, X Yun, H Pi, S Murray, Z Hill… - … of Physiology-Lung …, 2024 - journals.physiology.org
Pulmonary arterial hypertension (PAH) is a morbid disease characterized by significant lung
endothelial cell (EC) dysfunction. Prior work has shown that microvascular endothelial cells …

[HTML][HTML] Use of Raman spectroscopy to study rat lung tissues for distinguishing asphyxia from sudden cardiac death

K Zhang, R Liu, X Wei, Z Wang, P Huang - RSC advances, 2024 - pubs.rsc.org
Determining asphyxia as the cause of death is crucial but is based on an exclusive strategy
because it lacks sensitive and specific morphological characteristics in forensic practice. In …

A multimodal approach identifies lactate as a central feature of right ventricular failure that is detectable in human plasma

A Hemnes, N Fortune, K Simon, IA Trenary… - Frontiers in …, 2024 - frontiersin.org
Background In PAH metabolic abnormalities in multiple pathways are well-recognized
features of right ventricular dysfunction, however, prior work has focused mainly on the use …

[引用][C] 肺动脉高压代谢组学: 从病理机制到治疗靶点

邓渊瑞, 王晓建 - 基础医学与临床, 2024

[引用][C] Metabolomics of pulmonary hypertension: from pathological mechanisms to therapeutic targets

Y DENG, X WANG - Basic & Clinical Medicine, 2024