Intrinsic postzygotic barriers can play an important and multifaceted role in speciation, but
their contribution is often thought to be reserved to the final stages of the speciation process …

During meiosis, a programmed induction of DNA double-strand breaks (DSBs) leads to the
exchange of genetic material between homologous chromosomes. These exchanges …

Meiotic recombination involves the formation and repair of programmed DNA double-strand
breaks (DSBs) catalyzed by the conserved Spo11 protein. This review summarizes recent …

The DNA-binding protein PRDM9 has a critical role in specifying meiotic recombination
hotspots in mice and apes, but it appears to be absent from other vertebrate species …

Meiotic recombination events cluster into narrow segments of the genome, defined as
hotspots. Here, we demonstrate that a major player for hotspot specification is the Prdm9 …

Although present in both humans and chimpanzees, recombination hotspots, at which
meiotic crossover events cluster, differ markedly in their genomic location between the …

Genetic recombination occurs during meiosis, the key developmental programme of
gametogenesis. Recombination in mammals has been recently linked to the activity of a …

Mammalian meiotic recombination, which preferentially occurs at specialized sites called
hotspots, ensures the orderly segregation of meiotic chromosomes and creates genetic …

PRDM9 directs human meiotic crossover hot spots to intergenic sequence motifs, whereas
budding yeast hot spots overlap regions of low nucleosome density (LND) in gene …

Kruppel-associated box zinc-finger proteins (KRAB-ZFPs) make up the largest family of
transcription factors in humans. These proteins emerged in the last common ancestor of …