A review on Alzheimer's disease pathophysiology and its management: an update

A Kumar, A Singh - Pharmacological reports, 2015 - Elsevier
Alzheimer's disease acknowledged as progressive multifarious neurodegenerative disorder,
is the leading cause of dementia in late adult life. Pathologically it is characterized by …

Therapeutics of Alzheimer's disease: Past, present and future

R Anand, KD Gill, AA Mahdi - Neuropharmacology, 2014 - Elsevier
Alzheimer's disease (AD) is the most common cause of dementia worldwide. The etiology is
multifactorial, and pathophysiology of the disease is complex. Data indicate an exponential …

Bioinorganic chemistry of Alzheimer's disease

KP Kepp - Chemical reviews, 2012 - ACS Publications
Alzheimer's disease (AD) 1− 3 is the most common form of dementia (estimated∼ 50− 60%
of all cases), associated with loss of memory (in particular episodic memory), cognitive …

Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer's disease

RJ Baranello, KL Bharani, V Padmaraju… - Current Alzheimer …, 2015 - ingentaconnect.com
Amyloid-β proteins (Aβ) of 42 (Aβ42) and 40 aa (Aβ40) accumulate as senile plaques (SP)
and cerebrovascular amyloid protein deposits that are defining diagnostic features of …

Epigenetic regulation in the pathophysiology of Alzheimer's disease

L Chouliaras, BPF Rutten, G Kenis, O Peerbooms… - Progress in …, 2010 - Elsevier
With the aging of the population, the growing incidence and prevalence of Alzheimer's
disease (AD) increases the burden on individuals and society as a whole. To date, the …

[HTML][HTML] Epigenetic alterations in Alzheimer's disease

JV Sanchez-Mut, J Gräff - Frontiers in behavioral neuroscience, 2015 - frontiersin.org
Alzheimer's disease (AD) is the major cause of dementia in Western societies. It progresses
asymptomatically during decades before being belatedly diagnosed when therapeutic …

The LEARn model: an epigenetic explanation for idiopathic neurobiological diseases

DK Lahiri, B Maloney, NH Zawia - Molecular psychiatry, 2009 - nature.com
Neurobiological disorders have diverse manifestations and symptomology.
Neurodegenerative disorders, such as Alzheimer's disease, manifest late in life and are …

[HTML][HTML] DNA methylation, a hand behind neurodegenerative diseases

H Lu, X Liu, Y Deng, H Qing - Frontiers in aging neuroscience, 2013 - frontiersin.org
Epigenetic alterations represent a sort of functional modifications related to the genome that
are not responsible for changes in the nucleotide sequence. DNA methylation is one of such …

Vitamin D 3-enriched diet correlates with a decrease of amyloid plaques in the brain of AβPP transgenic mice

J Yu, M Gattoni-Celli, H Zhu, NR Bhat… - Journal of …, 2011 - content.iospress.com
In addition to its function in calcium and bone metabolism, vitamin D is neuroprotective and
important for mitigating inflammation. Alzheimer's disease (AD) is a progressive …

Early life epidemiology of Alzheimer's disease-a critical review

A Seifan, M Schelke, Y Obeng-Aduasare… - …, 2015 - karger.com
Background: As adult brain structure is primarily established in early life, genetic and
environmental exposures in infancy and childhood influence the risk for Alzheimer disease …