A review on Alzheimer's disease pathophysiology and its management: an update
A Kumar, A Singh - Pharmacological reports, 2015 - Elsevier
Alzheimer's disease acknowledged as progressive multifarious neurodegenerative disorder,
is the leading cause of dementia in late adult life. Pathologically it is characterized by …
is the leading cause of dementia in late adult life. Pathologically it is characterized by …
Therapeutics of Alzheimer's disease: Past, present and future
Alzheimer's disease (AD) is the most common cause of dementia worldwide. The etiology is
multifactorial, and pathophysiology of the disease is complex. Data indicate an exponential …
multifactorial, and pathophysiology of the disease is complex. Data indicate an exponential …
Bioinorganic chemistry of Alzheimer's disease
KP Kepp - Chemical reviews, 2012 - ACS Publications
Alzheimer's disease (AD) 1− 3 is the most common form of dementia (estimated∼ 50− 60%
of all cases), associated with loss of memory (in particular episodic memory), cognitive …
of all cases), associated with loss of memory (in particular episodic memory), cognitive …
Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer's disease
RJ Baranello, KL Bharani, V Padmaraju… - Current Alzheimer …, 2015 - ingentaconnect.com
Amyloid-β proteins (Aβ) of 42 (Aβ42) and 40 aa (Aβ40) accumulate as senile plaques (SP)
and cerebrovascular amyloid protein deposits that are defining diagnostic features of …
and cerebrovascular amyloid protein deposits that are defining diagnostic features of …
Epigenetic regulation in the pathophysiology of Alzheimer's disease
With the aging of the population, the growing incidence and prevalence of Alzheimer's
disease (AD) increases the burden on individuals and society as a whole. To date, the …
disease (AD) increases the burden on individuals and society as a whole. To date, the …
[HTML][HTML] Epigenetic alterations in Alzheimer's disease
JV Sanchez-Mut, J Gräff - Frontiers in behavioral neuroscience, 2015 - frontiersin.org
Alzheimer's disease (AD) is the major cause of dementia in Western societies. It progresses
asymptomatically during decades before being belatedly diagnosed when therapeutic …
asymptomatically during decades before being belatedly diagnosed when therapeutic …
The LEARn model: an epigenetic explanation for idiopathic neurobiological diseases
Neurobiological disorders have diverse manifestations and symptomology.
Neurodegenerative disorders, such as Alzheimer's disease, manifest late in life and are …
Neurodegenerative disorders, such as Alzheimer's disease, manifest late in life and are …
[HTML][HTML] DNA methylation, a hand behind neurodegenerative diseases
H Lu, X Liu, Y Deng, H Qing - Frontiers in aging neuroscience, 2013 - frontiersin.org
Epigenetic alterations represent a sort of functional modifications related to the genome that
are not responsible for changes in the nucleotide sequence. DNA methylation is one of such …
are not responsible for changes in the nucleotide sequence. DNA methylation is one of such …
Vitamin D 3-enriched diet correlates with a decrease of amyloid plaques in the brain of AβPP transgenic mice
In addition to its function in calcium and bone metabolism, vitamin D is neuroprotective and
important for mitigating inflammation. Alzheimer's disease (AD) is a progressive …
important for mitigating inflammation. Alzheimer's disease (AD) is a progressive …
Early life epidemiology of Alzheimer's disease-a critical review
A Seifan, M Schelke, Y Obeng-Aduasare… - …, 2015 - karger.com
Background: As adult brain structure is primarily established in early life, genetic and
environmental exposures in infancy and childhood influence the risk for Alzheimer disease …
environmental exposures in infancy and childhood influence the risk for Alzheimer disease …