Transcription factors (TFs) constitute a diverse class of sequence-specific DNA-binding
proteins, which are key to the modulation of gene expression. TFs have been associated …

We present a new approach for the identification of inhibitors of phosphorylation‐dependent
protein–protein interaction domains, in which phenolic fragments are adapted by in silico O …

The transcription factors STAT5a and STAT5b are constitutively active in many human
tumors. Combined inhibition of both STAT5 proteins is a valuable approach with promising …

The transcription factor STAT5a is a potential target for tumor therapy. We present a
fluorescence polarization-based, high-throughput screen of chemical libraries containing …

Although naturally occurring low‐molecular‐weight compounds have many known roles
within the cell, these do not usually involve the direct inhibition of protein–protein …

We recently presented Stafia‐1 as the first chemical entity that inhibits the transcription factor
STAT5a with selectivity over the highly homologous STAT5b. Stafia‐1, which was identified …

Fosfosal is the O‐phosphorylated derivative of salicylic acid, with documented clinical use
as a prodrug for the treatment of inflammatory diseases. We recently discovered that fosfosal …