Vascular disease and heart failure impart an enormous burden in terms of global morbidity
and mortality. Although there are many different causes of cardiac and vascular disease …

NADPH oxidases of the Nox family are important enzymatic sources of reactive oxygen
species (ROS). Numerous homologue-specific mechanisms control the activity of this …

Endothelium-derived nitric oxide (NO) is a paracrine factor that controls vascular tone,
inhibits platelet function, prevents adhesion of leukocytes, and reduces proliferation of the …

Cardiovascular risk factors lead to enhanced production of reactive oxygen species (ROS)
generated by NADPH oxidase, xanthine oxidase (XO), the mitochondrial electron-transport …

Endothelial cells control vascular homeostasis by generating paracrine factors that regulate
vascular tone, inhibit platelet function, prevent adhesion of leukocytes, and limit proliferation …

Oxidative stress is a key feature in atherogenesis, since reactive oxygen species (ROS) are
involved in all stages of the disease, from endothelial dysfunction to atheromatic plaque …

Reactive oxygen species (ROS) can be both beneficial and deleterious. Under normal
physiological conditions, ROS production is tightly regulated, and ROS participate in both …

Oxidative stress mediated by hyperglycaemia-induced generation of reactive oxygen
species (ROS) contributes significantly to the development and progression of diabetes and …

Disturbed cell autophagy is found in various cardiovascular disease conditions.
Biomechanical stimuli induced by laminar blood flow have important protective actions …

Recent research reveals that free bilirubin functions physiologically as a potent inhibitor of
NADPH oxidase activity. The chromophore phycocyanobilin (PCB), found in blue-green …