Maintaining mitochondrial health is emerging as a keystone in aging and associated
diseases. The selective degradation of mitochondria by mitophagy is of particular …

Lysosomal storage disorders (LSDs) are a vast group of more than 50 clinically identified
metabolic diseases. They are singly rare, but they affect collectively 1 on 5,000 live births …

This review discusses how lipophagy and cytosolic lipolysis degrade cellular lipids, as well
as how these pathway ys communicate, how they affect lipid metabolism and energy …

Lysosomal storage disorders (LSDs) result from an enzyme deficiency within lysosomes.
The systemic administration of the missing enzyme, however, is not effective in the case of …

Globoid cell leukodystrophy (GLD), also known as Krabbe disease, is a lysosomal storage
disorder causing extensive demyelination in the central and peripheral nervous systems …

Cancers and neurological disorders are two major types of diseases. We previously
developed a new concept termed “Aberrant Cell Cycle Diseases”(ACCD), revealing that …

Sanfilippo disease, caused by mutations in the genes encoding heparan sulfate (HS)(a
glycosaminoglycan; GAG) degradation enzymes, is a mucopolysaccharidosis (MPS), which …

Krabbe disease (KD) is a rare disorder arising from the deficiency of the lysosomal enzyme
galactosylceramidase (GALC), leading to the accumulation of the cytotoxic metabolite …

We have shown in vivo and in vitro previously that psychosine causes dysfunction of
autophagy and the ubiquitin-proteasome system underlying the pathogenesis of globoid cell …

Autophagic impairment was identified in many lysosomal storage diseases and adult
neurodegenerative diseases. It seems that this defect could be directly related to the …