Staphylococcus aureus host interactions and adaptation

BP Howden, SG Giulieri, T Wong Fok Lung… - Nature Reviews …, 2023 - nature.com
Invasive Staphylococcus aureus infections are common, causing high mortality,
compounded by the propensity of the bacterium to develop drug resistance. S. aureus is an …

Small molecule metabolites: discovery of biomarkers and therapeutic targets

S Qiu, Y Cai, H Yao, C Lin, Y Xie, S Tang… - Signal Transduction and …, 2023 - nature.com
Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …

Plasmonic alloys reveal a distinct metabolic phenotype of early gastric cancer

H Su, X Li, L Huang, J Cao, M Zhang… - Advanced …, 2021 - Wiley Online Library
Gastric cancer (GC) is a multifactorial process, accompanied by alterations in metabolic
pathways. Non‐invasive metabolic profiling facilitates GC diagnosis at early stage leading to …

ConSIG: consistent discovery of molecular signature from OMIC data

F Li, J Yin, M Lu, Q Yang, Z Zeng, B Zhang… - Briefings in …, 2022 - academic.oup.com
The discovery of proper molecular signature from OMIC data is indispensable for
determining biological state, physiological condition, disease etiology, and therapeutic …

A serum proteome signature to predict mortality in severe COVID-19 patients

F Völlmy, H Van Den Toorn, RZ Chiozzi… - Life Science …, 2021 - life-science-alliance.org
Here, we recorded serum proteome profiles of 33 severe COVID-19 patients admitted to
respiratory and intensive care units because of respiratory failure. We received, for most …

Multi-omics of human plasma reveals molecular features of dysregulated inflammation and accelerated aging in schizophrenia

A Campeau, RH Mills, T Stevens, LA Rossitto… - Molecular …, 2022 - nature.com
Schizophrenia is a devastating psychiatric illness that detrimentally affects a significant
portion of the worldwide population. Aging of schizophrenia patients is associated with …

Amplification of inflammation by lubricin deficiency implicated in incident, erosive gout independent of hyperuricemia

K Elsaid, TR Merriman, LA Rossitto… - Arthritis & …, 2023 - Wiley Online Library
Objective In gout, hyperuricemia promotes urate crystal deposition, which stimulates the
NLRP3 inflammasome and interleukin‐1β (IL‐1β)–mediated arthritis. Incident gout without …

Multi-omic analysis in injured humans: Patterns align with outcomes and treatment responses

J Wu, Y Vodovotz, S Abdelhamid, FX Guyette… - Cell Reports …, 2021 - cell.com
Trauma is a leading cause of death and morbidity worldwide. Here, we present the analysis
of a longitudinal multi-omic dataset comprising clinical, cytokine, endotheliopathy biomarker …

Population-wide diversity and stability of serum antibody epitope repertoires against human microbiota

T Vogl, S Klompus, S Leviatan, IN Kalka… - Nature medicine, 2021 - nature.com
Serum antibodies can recognize both pathogens and commensal gut microbiota. However,
our current understanding of antibody repertoires is largely based on DNA sequencing of …

Metabolomics meets systems immunology

J Fu, F Zhu, CJ Xu, Y Li - EMBO reports, 2023 - embopress.org
Metabolic processes play a critical role in immune regulation. Metabolomics is the
systematic analysis of small molecules (metabolites) in organisms or biological samples …