The tumor suppressor p53 functions primarily as a transcription factor. Mutation of the TP53
gene alters its response pathway, and is central to the development of many cancers. The …

One of the main engines that drives cellular transformation is the loss of proper control of the
mammalian cell cycle. The cyclin-dependent kinase inhibitor p21 (also known as …

While the tumor suppressor functions of p53 have long been recognized, the contribution of
p53 to numerous other aspects of disease and normal life is only now being appreciated …

The precise timing of cell cycle gene expression is critical for the control of cell proliferation;
de-regulation of this timing promotes the formation of cancer and leads to defects during …

The tumor suppressor p53 functions predominantly as a transcription factor by activating and
downregulating gene expression, leading to cell cycle arrest or apoptosis. p53 was shown to …

Telomerase is expressed in early human development and then becomes silenced in most
normal tissues. Because~ 90% of primary human tumors express telomerase and generally …

Over the past decade, there has been much interest in the regulation of telomerase, the
enzyme responsible for maintaining the integrity of chromosomal ends, and its crucial role in …

The ability of p53 to promote apoptosis and cell cycle arrest is believed to be important for its
tumor suppression function. Besides activating the expression of cell cycle arrest and …

Metabolic deregulation is a hallmark of human cancers, and the glycolytic and glutamine
metabolism pathways were shown to be deregulated in pancreatic ductal adenocarcinoma …

The predominant function of the tumor suppressor p53 is transcriptional regulation. It is
generally accepted that p53-dependent transcriptional activation occurs by binding to a …