A clinical, biological, and biomaterials perspective into tendon injuries and regeneration

G Walden, X Liao, S Donell, MJ Raxworthy… - … Engineering Part B …, 2017 - liebertpub.com
Tendon injury is common and debilitating, and it is associated with long-term pain and
ineffective healing. It is estimated to afflict 25% of the adult population and is often a career …

Structural architectures with toughening mechanisms in Nature: A review of the materials science of Type-I collagenous materials

W Yang, MA Meyers, RO Ritchie - Progress in Materials Science, 2019 - Elsevier
The structural constituents of tissues in organisms are composed primarily of minerals and
proteins. Collagen is the most common protein used to construct such natural materials in …

[HTML][HTML] The interfascicular matrix enables fascicle sliding and recovery in tendon, and behaves more elastically in energy storing tendons

CT Thorpe, MSC Godinho, GP Riley, HL Birch… - Journal of the …, 2015 - Elsevier
While the predominant function of all tendons is to transfer force from muscle to bone and
position the limbs, some tendons additionally function as energy stores, reducing the cost of …

[HTML][HTML] Hierarchical ultrastructure: an overview of what is known about tendons and future perspective for tendon engineering

S Zhang, W Ju, X Chen, Y Zhao, L Feng, Z Yin… - Bioactive materials, 2022 - Elsevier
Abnormal tendons are rarely ever repaired to the natural structure and morphology of
normal tendons. To better guide the repair and regeneration of injured tendons through a …

[HTML][HTML] Structure and collagen crimp patterns of functionally distinct equine tendons, revealed by quantitative polarised light microscopy (qPLM)

EM Spiesz, CT Thorpe, PJ Thurner, HRC Screen - Acta biomaterialia, 2018 - Elsevier
Abstract Structure-function relationships in tendons are directly influenced by the
arrangement of collagen fibres. However, the details of such arrangements in functionally …

[HTML][HTML] Fascicles and the interfascicular matrix show adaptation for fatigue resistance in energy storing tendons

CT Thorpe, GP Riley, HL Birch, PD Clegg, HRC Screen - Acta biomaterialia, 2016 - Elsevier
Tendon is composed of rope-like fascicles, bound together by interfascicular matrix (IFM).
Our previous work shows that the IFM is critical for tendon function, facilitating sliding …

Effects of Low‐Intensity Pulsed Ultrasound in Tendon Injuries

Y Li, W Li, X Liu, X Liu, B Zhu, S Guo… - … of Ultrasound in …, 2023 - Wiley Online Library
Tendon injuries are the most common soft tissue injuries, caused by tissue overuse and age‐
related degeneration. However, the tendon repair process is slow and inefficient due to the …

[HTML][HTML] Exosomes derived from human umbilical cord mesenchymal stem cells reduce tendon injuries via the miR-27b-3p/ARHGAP5/RhoA signaling pathway …

Q Han, S Wang, D Chen, D Gan… - Acta Biochimica et …, 2022 - ncbi.nlm.nih.gov
Tendon injuries are common clinical issues resulted from tissue overuse and age-related
degeneration. Previous sutdies have suggested that exosomes secreted by mesenchymal …

Tendon physiology and mechanical behavior: structure–function relationships

CT Thorpe, HL Birch, PD Clegg, HRC Screen - Tendon regeneration, 2015 - Elsevier
Tendons are composed of highly aligned collagen, arranged along the long axis for tensile
strength. The collagen is arranged in a series of hierarchical levels, surrounded at each …

[PDF][PDF] Variations during ageing in the three-dimensional anatomical arrangement of fascicles within the equine superficial digital flexor tendon

OJ Ali, EJ Comerford, PD Clegg, EG Canty-Laird - Eur Cell Mater, 2018 - ecmjournal.org
Tendons are constructed from collagenous fascicles separated by endotenon/interfascicular
matrix (IFM). Tendons may be specialised for precision movement or to store energy during …