Lactate dehydrogenase (LDH) is a terminating enzyme in the metabolic pathway of
anaerobic glycolysis with end product of lactate from glucose. The lactate formation is crucial …

Malaria is a vector-borne parasitic disease caused by the apicomplexan protozoan parasite
Plasmodium. Malaria is a significant health problem and the leading cause of …

The deadliest disease caused by the Plasmodium species is malaria. Among other species,
the infection caused by Plasmodium falciparum (Pf) is life-threatening. The biological …

Malaria, a devastating infectious disease caused by Plasmodium spp., leads to roughly
655,000 deaths per year, mostly of African children. To compound the problem, drug …

Neglected tropical diseases cause significant morbidity and mortality and are a source of
poverty in endemic countries. Only a few drugs are available to treat diseases such as …

Polygala boliviensis is found in the Brazilian semiarid region. This specie is little chemically
and biologically studied. Polygala spp. have different metabolites, especially coumarins …

The apicoplast, a relict plastid found in most species of the phylum Apicomplexa, harbors the
ferredoxin redox system which supplies electrons to enzymes of various metabolic pathways …

In the attempt of developing innovative anticancer treatments, growing interest has recently
focused on the peculiar metabolic properties of cancer cells. In this context, LDH, which …

Parasitic diseases remain a major public health concern for humans, claiming millions of
lives annually. Although different treatments are required for these diseases, drug usage is …

Based on the structures of isoxaflutole (IFT) and N-isobutyl-N-(4-chloro-benzyl)-4-chloro-2-
pentenamide, a series of N-benzyl-5-cyclopropyl-isoxazole-4-carboxamides was designed …