[HTML][HTML] A tough act to follow: Collagen hydrogel modifications to improve mechanical and growth factor loading capabilities
Collagen hydrogels are among the most well-studied platforms for drug delivery and in situ
tissue engineering, thanks to their low cost, low immunogenicity, versatility, biocompatibility …
tissue engineering, thanks to their low cost, low immunogenicity, versatility, biocompatibility …
Functional and biomimetic materials for engineering of the three-dimensional cell microenvironment
The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …
Local 3D matrix microenvironment regulates cell migration through spatiotemporal dynamics of contractility-dependent adhesions
AD Doyle, N Carvajal, A Jin, K Matsumoto… - Nature …, 2015 - nature.com
The physical properties of two-dimensional (2D) extracellular matrices (ECMs) modulate cell
adhesion dynamics and motility, but little is known about the roles of local …
adhesion dynamics and motility, but little is known about the roles of local …
The molecular interaction of collagen with cell receptors for biological function
J Elango, C Hou, B Bao, S Wang… - Polymers, 2022 - mdpi.com
Collagen, an extracellular protein, covers the entire human body and has several important
biological functions in normal physiology. Recently, collagen from non-human sources has …
biological functions in normal physiology. Recently, collagen from non-human sources has …
Collagen microarchitecture mechanically controls myofibroblast differentiation
Altered microarchitecture of collagen type I is a hallmark of wound healing and cancer that is
commonly attributed to myofibroblasts. However, it remains unknown which effect collagen …
commonly attributed to myofibroblasts. However, it remains unknown which effect collagen …
Self-generated gradients steer collective migration on viscoelastic collagen networks
Growing evidence suggests that the physical properties of the cellular microenvironment
influence cell migration. However, it is not currently understood how active physical …
influence cell migration. However, it is not currently understood how active physical …
The role of network architecture in collagen mechanics
Collagen forms fibrous networks that reinforce tissues and provide an extracellular matrix for
cells. These networks exhibit remarkable strain-stiffening properties that tailor the …
cells. These networks exhibit remarkable strain-stiffening properties that tailor the …
3D in vitro M2 macrophage model to mimic modulation of tissue repair
Distinct anti-inflammatory macrophage (M2) subtypes, namely M2a and M2c, are reported to
modulate the tissue repair process tightly and chronologically by modulating fibroblast …
modulate the tissue repair process tightly and chronologically by modulating fibroblast …
In vitro 3D cultures to model the tumor microenvironment
F Fontana, M Marzagalli, M Sommariva, N Gagliano… - Cancers, 2021 - mdpi.com
Simple Summary Tumor stroma is known to significantly influence cancer initiation and
progression. In the last decade, 3D cell cultures have shown potential in modeling the tumor …
progression. In the last decade, 3D cell cultures have shown potential in modeling the tumor …
Effect of nuclear stiffness on cell mechanics and migration of human breast cancer cells
T Fischer, A Hayn, CT Mierke - Frontiers in cell and developmental …, 2020 - frontiersin.org
The migration and invasion of cancer cells through 3D confined extracellular matrices is
coupled to cell mechanics and the mechanics of the extracellular matrix. Cell mechanics is …
coupled to cell mechanics and the mechanics of the extracellular matrix. Cell mechanics is …