The process of neurogenesis is well orchestrated by the harmony of multiple cues in a
spatiotemporal manner. In this review, we focus on how a dynamic gene, Hes1, is involved …

Cardiac valve stenosis and calcification is estimated to affect over 500 million people by
2050 (d'Arcy et al., 2016). Calcification refers to the mineralization in soft tissues causing …

Neural stem cells are self-renewing, multipotent and undifferentiated precursors that retain
the capacity for differentiation into both glial (astrocytes and oligodendrocytes) and neuronal …

Tlx3, a master regulator of the fate specification of excitatory neurons, is primarily known to
function in post-mitotic cells. Although we have previously identified TLX3 expression in the …

Abstract Delta-like ligand-4 (DLL4)-Notch signaling is known to play a pivotal role in the
regulation of tumor angiogenesis. We had previously found that DLL4 was overexpressed …

TLX3 has an established role as a sequence-specific transcription factor with vital functions
in the nervous system. Although several studies have shown that TLX3 is aberrantly up …

Homeobox gene Tlx3 is known to promote glutamatergic differentiation and is expressed in
post-mitotic neurons of CNS. Contrary to this here, we discovered that Tlx3 is expressed in …

Differential regulation of Brn3b is essential for the Retinal Ganglion Cell (RGC) development
in the two phases of retinal histogenesis. This biphasic Brn3b regulation is required first …

Retinal histogenesis requires coordinated and temporal functioning of factors by which
different cell types are generated from multipotent progenitors. Development of rod …

Embryonic stem (ES) and induced pluripotent stem (iPS) cells are attractive tools for
regenerative medicine therapies. However, aberrant cell populations that display flattened …