Advances in development and application of influenza vaccines
J Chen, J Wang, J Zhang, H Ly - Frontiers in immunology, 2021 - frontiersin.org
Influenza A virus is one of the most important zoonotic pathogens that can cause severe
symptoms and has the potential to cause high number of deaths and great economic loss …
symptoms and has the potential to cause high number of deaths and great economic loss …
Vaccines against tuberculosis: where are we and where do we need to go?
THM Ottenhoff, SHE Kaufmann - PLoS pathogens, 2012 - journals.plos.org
In this review we discuss recent progress in the development, testing, and clinical evaluation
of new vaccines against tuberculosis (TB). Over the last 20 years, tremendous progress has …
of new vaccines against tuberculosis (TB). Over the last 20 years, tremendous progress has …
[HTML][HTML] Identification of a Kupffer cell subset capable of reverting the T cell dysfunction induced by hepatocellular priming
Kupffer cells (KCs) are highly abundant, intravascular, liver-resident macrophages known for
their scavenger and phagocytic functions. KCs can also present antigens to CD8+ T cells …
their scavenger and phagocytic functions. KCs can also present antigens to CD8+ T cells …
Dynamics and genomic landscape of CD8+ T cells undergoing hepatic priming
AP Bénéchet, G De Simone, P Di Lucia, F Cilenti… - Nature, 2019 - nature.com
The responses of CD8+ T cells to hepatotropic viruses such as hepatitis B range from
dysfunction to differentiation into effector cells, but the mechanisms that underlie these …
dysfunction to differentiation into effector cells, but the mechanisms that underlie these …
Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses
Vaccines based on recombinant proteins avoid the toxicity and antivector immunity
associated with live vaccine (for example, viral) vectors, but their immunogenicity is poor …
associated with live vaccine (for example, viral) vectors, but their immunogenicity is poor …
The Alarmin Interleukin-33 Drives Protective Antiviral CD8+ T Cell Responses
WV Bonilla, A Fröhlich, K Senn, S Kallert, M Fernandez… - Science, 2012 - science.org
Pathogen-associated molecular patterns decisively influence antiviral immune responses,
whereas the contribution of endogenous signals of tissue damage, also known as damage …
whereas the contribution of endogenous signals of tissue damage, also known as damage …
[HTML][HTML] New viral vectors for infectious diseases and cancer
E Sasso, AM D'Alise, N Zambrano, E Scarselli… - Seminars in …, 2020 - Elsevier
Since the discovery in 1796 by Edward Jenner of vaccinia virus as a way to prevent and
finally eradicate smallpox, the concept of using a virus to fight another virus has evolved into …
finally eradicate smallpox, the concept of using a virus to fight another virus has evolved into …
High antigen levels induce an exhausted phenotype in a chronic infection without impairing T cell expansion and survival
Chronic infections induce T cells showing impaired cytokine secretion and up-regulated
expression of inhibitory receptors such as PD-1. What determines the acquisition of this …
expression of inhibitory receptors such as PD-1. What determines the acquisition of this …
Development and applications of viral vectored vaccines to combat zoonotic and emerging public health threats
Vaccination is arguably the most cost-effective preventative measure against infectious
diseases. While vaccines have been successfully developed against certain viruses (eg …
diseases. While vaccines have been successfully developed against certain viruses (eg …
Arenavirus glycan shield promotes neutralizing antibody evasion and protracted infection
R Sommerstein, L Flatz, MM Remy, P Malinge… - PLoS …, 2015 - journals.plos.org
Arenaviruses such as Lassa virus (LASV) can cause severe hemorrhagic fever in humans.
As a major impediment to vaccine development, delayed and weak neutralizing antibody …
As a major impediment to vaccine development, delayed and weak neutralizing antibody …