The APOBEC family of single-stranded DNA cytosine deaminases comprises a formidable
arm of the vertebrate innate immune system. Pre-vertebrates express a single APOBEC …

Apolipoprotein B editing complex 3 family members are cytidine deaminases that play
important roles in intrinsic responses to infection by retroviruses and have been implicated …

Abstract Serine Incorporator 5 (SERINC5), a cellular multipass transmembrane protein that
is involved in sphingolipid and phosphatydilserine biogenesis, potently restricts a number of …

Highlights•Endogenous retroviruses as remnants of ancestral germline infections.•Ongoing
endogenisation of infectious retroviruses reported in some mammals.•Possible evolution …

Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (APOBEC) proteins are a
diverse and evolutionarily conserved family of cytidine deaminases that provide a variety of …

Host recognition of viral nucleic acids generated during infection leads to the activation of
innate immune responses essential for early control of virus. Retrovirus reverse transcription …

Viruses rely on hosts for life and reproduction, cause a variety of symptoms from common
cold to AIDS to COVID-19 and provoke public health threats claiming millions of lives around …

The mouse gammaretroviruses associated with leukemogenesis are found in the classical
inbred mouse strains and in house mouse subspecies as infectious exogenous viruses …

Cytosolic DNAs derived from retrotransposons serve as pathogen-associated molecular
patterns for pattern recognition receptors (PRRs) that stimulate the induction of interferons …

Intrinsic restriction factors and viral nucleic acid sensors are important for the anti-viral
response. Here, we show how upstream sensing of retroviral reverse transcripts integrates …