The immunobiology of preterm labor and birth: intra-amniotic inflammation or breakdown of maternal–fetal homeostasis
In brief The syndrome of preterm labor comprises multiple established and novel etiologies.
This review summarizes the distinct immune mechanisms implicated in preterm labor and …
This review summarizes the distinct immune mechanisms implicated in preterm labor and …
Vaginal progesterone for preventing preterm birth and adverse perinatal outcomes in singleton gestations with a short cervix: a meta-analysis of individual patient data
R Romero, A Conde-Agudelo, E Da Fonseca… - American journal of …, 2018 - Elsevier
Background The efficacy of vaginal progesterone for preventing preterm birth and adverse
perinatal outcomes in singleton gestations with a short cervix has been questioned after …
perinatal outcomes in singleton gestations with a short cervix has been questioned after …
Acute chorioamnionitis and funisitis: definition, pathologic features, and clinical significance
Acute inflammatory lesions of the placenta consist of diffuse infiltration of neutrophils at
different sites in the organ. These lesions include acute chorioamnionitis, funisitis, and …
different sites in the organ. These lesions include acute chorioamnionitis, funisitis, and …
Microbial changes during pregnancy, birth, and infancy
Several healthy developmental processes such as pregnancy, fetal development, and infant
development include a multitude of physiological changes: weight gain, hormonal, and …
development include a multitude of physiological changes: weight gain, hormonal, and …
Chorioamnionitis and neonatal outcomes
Chorioamnionitis or intrauterine inflammation is a frequent cause of preterm birth.
Chorioamnionitis can affect almost every organ of the developing fetus. Multiple microbes …
Chorioamnionitis can affect almost every organ of the developing fetus. Multiple microbes …
Does the human placenta delivered at term have a microbiota? Results of cultivation, quantitative real-time PCR, 16S rRNA gene sequencing, and metagenomics
Background The human placenta has been traditionally viewed as sterile, and microbial
invasion of this organ has been associated with adverse pregnancy outcomes. Yet, recent …
invasion of this organ has been associated with adverse pregnancy outcomes. Yet, recent …
The frequency and type of placental histologic lesions in term pregnancies with normal outcome
Objective To determine the frequency and type of histopathologic lesions in placentas
delivered by women with a normal pregnancy outcome. Methods This retrospective cohort …
delivered by women with a normal pregnancy outcome. Methods This retrospective cohort …
[HTML][HTML] Evidence that intra-amniotic infections are often the result of an ascending invasion–a molecular microbiological study
Background Microbial invasion of the amniotic cavity resulting in intra-amniotic infection is
associated with obstetrical complications such as preterm labor with intact or ruptured …
associated with obstetrical complications such as preterm labor with intact or ruptured …
Antibiotic administration can eradicate intra-amniotic infection or intra-amniotic inflammation in a subset of patients with preterm labor and intact membranes
Background Intra-amniotic infection is present in 10% of patients with an episode of preterm
labor, and is a risk factor for impending preterm delivery and neonatal morbidity/mortality …
labor, and is a risk factor for impending preterm delivery and neonatal morbidity/mortality …
Spontaneous preterm birth: advances toward the discovery of genetic predisposition
Evidence from family and twin-based studies provide strong support for a significant
contribution of maternal and fetal genetics to the timing of parturition and spontaneous …
contribution of maternal and fetal genetics to the timing of parturition and spontaneous …