Parkinson's disease (PD) is a progressive neurodegenerative disease where dopaminergic
neurons in the substantia nigra are lost, resulting in a decrease in striatal dopamine and …

Parkinson's disease (PD) is a progressive neurodegenerative disorder resulting from the
death of dopamine neurons in the substantia nigra pars compacta. Our understanding of PD …

Many neurodegenerative diseases are characterized by abnormal protein aggregates,
including the two most common neurodegenerative diseases Alzheimer's disease (AD) and …

In recent years, multiple lines of evidence from human genetic and molecular studies have
highlighted the importance of the autophagy lysosomal pathway (ALP) in Parkinson's …

Background Autosomal recessive mutations in the glucocerebrosidase gene, Beta‐
glucocerebrosidase 1 (GBA1), cause the lysosomal storage disorder Gaucher's disease …

Background Gaucher disease (GD) is a rare, inherited, autosomal recessive disorder
caused by a deficiency of the lysosomal enzyme, acid β-glucosidase. Its diagnosis is …

Glycosphingolipids are important building blocks of the outer leaflet of the cell membrane.
They are continuously recycled, involving fragmentation inside lysosomes by glycosidases …

Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons in the
substantia nigra and subsequent motor symptoms, but various non-motor symptoms (NMS) …

Accumulation of the protein α-synuclein into insoluble intracellular deposits termed Lewy
bodies (LBs) is the characteristic neuropathological feature of LB diseases, such as …

As our understanding of GBA1-associated Parkinson disease increases, new treatment
opportunities emerge. MicroRNA profiles are providing examples of both up-regulated and …