The Janus (dual) model of immunoglobulin isotype evolution: Conservation and plasticity are the defining paradigms
MF Flajnik - Immunological Reviews, 2024 - Wiley Online Library
The study of antibodies in jawed vertebrates (gnathostomes) provides every immunologist
with a bird's eye view of how human immunoglobulins (Igs) came into existence and …
with a bird's eye view of how human immunoglobulins (Igs) came into existence and …
An ancient MHC-linked gene encodes a nonrearranging shark antibody, UrIg, convergent with IgG
MF Flajnik, R Stanfield, EN Pokidysheva… - The Journal of …, 2023 - journals.aai.org
Gnathostome adaptive immunity is defined by the Ag receptors, Igs and TCRs, and the MHC.
Cartilaginous fish are the oldest vertebrates with these adaptive hallmarks. We and others …
Cartilaginous fish are the oldest vertebrates with these adaptive hallmarks. We and others …
Genomic view of the origins of cell-mediated immunity
NKp30 is an activating natural killer cell receptor (NKR) with a single-exon variable (VJ)–
type immunoglobulin superfamily (IgSF) domain. Such VJ-IgSF domains predate the …
type immunoglobulin superfamily (IgSF) domain. Such VJ-IgSF domains predate the …
An Ancestral Major Histocompatibility Complex Organization in Cartilaginous Fish: Reconstructing MHC Origin and Evolution
A Veríssimo, LFC Castro… - Molecular Biology …, 2023 - academic.oup.com
Cartilaginous fish (sharks, rays, and chimeras) comprise the oldest living jawed vertebrates
with a mammalian-like adaptive immune system based on immunoglobulins (Ig), T-cell …
with a mammalian-like adaptive immune system based on immunoglobulins (Ig), T-cell …
Evolutionary Analysis of the Mammalian IL‐17 Cytokine Family Suggests Conserved Roles in Female Fertility
F Giangrazi, D Buffa, AT Lloyd… - American Journal of …, 2024 - Wiley Online Library
ABSTRACT Problem The interleukin‐17 (IL‐17) family includes pro‐inflammatory cytokines
IL‐17A‐F with important roles in mucosal defence, barrier integrity and tissue regeneration …
IL‐17A‐F with important roles in mucosal defence, barrier integrity and tissue regeneration …
Fundamental Characterization of Antibody Fusion-Single-Chain TNF Recombinant Proteins Directed against Costimulatory TNF Receptors Expressed by T …
H Nagai, M Azuma, A Sato, N Shibui, S Ogawara… - Cells, 2023 - mdpi.com
The costimulatory signal regulated by the members of the tumor necrosis factor receptor
(TNFR) superfamily expressed by T cells plays essential roles for T cell responses and has …
(TNFR) superfamily expressed by T cells plays essential roles for T cell responses and has …