The effects of epithelial–mesenchymal transitions in COPD induced by cigarette smoke: an update

X Su, W Wu, Z Zhu, X Lin, Y Zeng - Respiratory research, 2022 - Springer
Cigarette smoke is a complex aerosol containing a large number of compounds with a
variety of toxicity and carcinogenicity. Long-term exposure to cigarette smoke significantly …

Targeting inflammation in non-small cell lung cancer through drug repurposing

T Rajasegaran, CW How, A Saud, A Ali, JCW Lim - Pharmaceuticals, 2023 - mdpi.com
Lung cancer is the most common cause of cancer-related deaths. Lung cancers can be
classified as small-cell (SCLC) or non-small cell (NSCLC). About 84% of all lung cancers …

The underappreciated role of epithelial mesenchymal transition in chronic obstructive pulmonary disease and its strong link to lung cancer

MQ Mahmood, SD Shukla, C Ward, EH Walters - Biomolecules, 2021 - mdpi.com
The World Health Organisation reported COPD to be the third leading cause of death
globally in 2019, and in 2020, the most common cause of cancer death was lung cancer; …

Fully integrating pathophysiological insights in COPD: an updated working disease model to broaden therapeutic vision

EH Walters, SD Shukla, MQ Mahmood… - European Respiratory …, 2021 - Eur Respiratory Soc
Our starting point is that relatively new findings into the pathogenesis and pathophysiology
of airway disease in smokers that lead to chronic obstructive pulmonary disease (COPD) …

Low-dose aspirin and incidence of lung carcinoma in patients with chronic obstructive pulmonary disease in Hong Kong: A cohort study

SY Yu, MSM Ip, X Li, KS Cheung, QW Ren… - PLoS …, 2022 - journals.plos.org
Background Evidence suggests that chronic obstructive pulmonary disease (COPD) is
associated with a higher risk of lung carcinoma. Using a territory-wide clinical electronic …

Chinese herbs and repurposing old drugs as therapeutic agents in the regulation of oxidative stress and inflammation in pulmonary diseases

CC Yang, CM Yang - Journal of Inflammation Research, 2021 - Taylor & Francis
Several pro-inflammatory factors and proteins have been characterized that are involved in
the pathogenesis of inflammatory diseases, including acute respiratory distress syndrome …

The State of Use and Utility of Negative Controls in Pharmacoepidemiologic Studies

Z Zafari, J Park, CH Shah, S Dosreis… - American Journal of …, 2024 - academic.oup.com
Uses of real-world data in drug safety and effectiveness studies are often challenged by
various sources of bias. We undertook a systematic search of the published literature …

Statin use as a moderator on the association between metformin and breast cancer risk in women with type 2 diabetes mellitus

F Zhang, GH de Bock, GW Landman, Q Zhang… - Cancer & …, 2024 - Springer
Introduction Metformin and statins are considered as potential agents for prevention of
breast cancer, however, existing evidence does not uniformly substantiate this claim, and …

Genetic alterations and deregulation of hippo pathway as a pathogenetic mechanism in bone and soft tissue sarcoma

C Salguero-Aranda, J Olmedo-Pelayo, E de Álava… - Cancers, 2022 - mdpi.com
Simple Summary Cancer is a genetic disease that is caused by changes in genes
controlling cell growth, migration, and differentiation. Usually, cancer cells hijack processes …

[HTML][HTML] Nuevos avances terapéuticos en pacientes con cáncer de pulmón inmunosuprimidos con enfermedades crónicas pulmonares en el periodo 2014-2022 a …

FM Escalante, CL Díaz, DF Guillén - Revista española de salud …, 2023 - ncbi.nlm.nih.gov
El cáncer de pulmón es una neoplasia maligna de gran prevalencia y mortalidad, más en
pacientes con comorbilidades respiratorias, cuyas células tienen una capacidad de …