Electroporation is a membrane phenomenon which involves fundamental behavior of cell
and artificial bilayer membranes, and increasingly attracts consideration for applications in …

Surfactants are used to stabilize biologics. Particularly, polysorbates (Tween® 20 and
Tween® 80) dominate the group of surfactants in protein and especially antibody drug …

Electroporation designates the use of short high‐voltage pulses to overcome the barrier of
the cell membrane. By applying an external electric field, which just surpasses the …

Duchenne muscular dystrophy (DMD) is a severe, progressive, and ultimately fatal disease
of skeletal muscle wasting, respiratory insufficiency, and cardiomyopathy. The identification …

Electroporation is a fascinating cell membrane phenomenon with several existing biological
applications and others likely. Although DNA introduction is the most common use …

We present results of molecular dynamics simulations of lipid bilayers under a high
transverse electrical field aimed at investigating their electroporation. Several systems are …

Electrical pulses that cause the transmembrane voltage of fluid lipid bilayer membranes to
reach at least U/sub m//spl ap/0.2 V, usually 0.5-1 V, are hypothesized to create primary …

RNAi technology has brought a new category of treatments for various diseases including
genetic diseases, viral diseases, and cancer. Despite the great versatility of RNAi that can …

β-Sitosterol is a well known phytosterol in plants, but owing to its poor solubility in typical
media, determining its cellular mechanisms has been proven to be difficult. In this study, we …

Application of strong electric field pulses to cells and tissue is known to cause some type of
structural rearrangement of the cell membrane. Significant progress has been made by …