Myc (avian myelocytomatosis viral oncogene homolog) represents one of the most sought
after drug targets in cancer. Myc transcription factor is an essential regulator of cell growth …

AG‐quadruplex is a nucleic acid secondary structure that is adopted by guanine‐rich
sequences, and is considered to be relevant in various pharmacological and biological …

Conspectus The digitization of chemistry is not simply about using machine learning or
artificial intelligence systems to process chemical data, or about the development of ever …

The nuclear transcription factor c-Myc is a member of the Myc gene family with multiple
functions and located on band q24. 1 of chromosome 8. The c-Myc gene is activated by …

Approved drugs have favourable or validated pharmacokinetic properties and toxicological
profiles, and the repositioning of existing drugs for new indications can potentially avoid …

In this study, the reported G-quadruplex groove binder benzo [d, e] isoquinoline was linked
to a cyclometallated Ir (III) complex to generate a highly selective DNA probe 1 that retains …

The structural differences among different G-quadruplexes provide an opportunity for site-
specific targeting of a particular G-quadruplex structure. However, majority of G-quadruplex …

Small molecule ligands that could stabilize G-quadruplex structure formed at the promoter
region of human c-myc oncogene will regulate its expression in cancer cells. Flavonoids, a …

Sensors capable of transducing G-quadruplex DNA binding are important both in solution
and for imaging and interrogation in cellulo. Ru (II)-based light switches incorporating …

Over the past two decades biologists and bioinformaticians have unearthed substantial
evidence supporting a role for G-quadruplexes as important mediators of biological …