Fluorescence is one of the techniques adopted for a large number of optical bioassays and
chemical sensing probes. The key driving motivation is basically governed by the ease of …

The bioluminescence signal generated by the luciferase-luciferin interaction, exploited for
real-time and continuous monitoring of numerous biochemical processes in living cells and …

The therapeutic action of drugs is predicated on their physical engagement with cellular
targets. Here we describe a broadly applicable method using bioluminescence resonance …

Protein biosensors play increasingly important roles in cell and neurobiology and have the
potential to revolutionise the way clinical and industrial analytics are performed. The gradual …

FRET-based caspase activity probes have become important tools to monitor apoptotic cell
signaling. However, their dependence on external illumination is incompatible with light …

Cell surface G protein-coupled receptors (GPCRs) drive numerous signaling pathways
involved in the regulation of a broad range of physiologic processes. Today, they represent …

Bioluminescence imaging of live cells has recently been recognized as an important
alternative to fluorescence imaging. Fluorescent probes are much brighter than …

Bioluminescence resonance energy transfer (BRET) is an important tool for monitoring
macromolecular interactions and is useful as a transduction technique for biosensor …

PML, the organizer of nuclear bodies (NBs), is expressed in several isoforms designated
PMLI to VII which differ in their C-terminal region due to alternative splicing of a single gene …

Each step of the cell life and its response or adaptation to its environment are mediated by a
network of protein/protein interactions termed “interactome.” Our knowledge of this network …