Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies
NI Edman, A Phal, RL Redler, T Schlichthaerle… - Cell, 2024 - cell.com
Many growth factors and cytokines signal by binding to the extracellular domains of their
receptors and driving association and transphosphorylation of the receptor intracellular …
receptors and driving association and transphosphorylation of the receptor intracellular …
Designed endocytosis-inducing proteins degrade targets and amplify signals
Endocytosis and lysosomal trafficking of cell surface receptors can be triggered by
endogenous ligands. Therapeutic approaches such as lysosome-targeting …
endogenous ligands. Therapeutic approaches such as lysosome-targeting …
De novo design of high-affinity protein binders with AlphaProteo
V Zambaldi, D La, AE Chu, H Patani… - arXiv preprint arXiv …, 2024 - arxiv.org
Computational design of protein-binding proteins is a fundamental capability with broad
utility in biomedical research and biotechnology. Recent methods have made strides against …
utility in biomedical research and biotechnology. Recent methods have made strides against …