Infection with Mycobacterium ulcerans results in a necrotising skin disease known as a
Buruli ulcer, the pathology of which is directly linked to the bacterial production of the toxin …

Buruli ulcer is a noncontagious disabling cutaneous and subcutaneous mycobacteriosis
reported by 33 countries in Africa, Asia, Oceania, and South America. The causative agent …

Infection with Mycobacterium ulcerans is characterised by tissue necrosis and
immunosuppression due to mycolactone, the necessary and sufficient virulence factor for …

Mycolactone, an immunosuppressive macrolide released by the human pathogen
Mycobacterium ulcerans, was previously shown to impair Sec61-dependent protein …

Infection of subcutaneous tissue with Mycobacterium ulcerans can lead to chronic skin
ulceration known as Buruli ulcer. The pathogenesis of this neglected tropical disease is …

Background. Antimicrobial killing in mycobacterial infections may be accompanied by
(transient) clinical deterioration, known as paradoxical reaction. To search for patterns …

Buruli ulcer (BU), the third most common mycobacterial infection in humans next to
tuberculosis and leprosy, is an emerging infection caused by Mycobacterium ulcerans. BU is …

Mycolactone is a bacteria-derived macrolide that blocks the biogenesis of a large array of
secretory and integral transmembrane proteins (TMP) through potent inhibition of the Sec61 …

Mycolactone is a diffusible lipid toxin produced by Mycobacterium ulcerans, the causative
agent of a necrotizing skin disease referred to as Buruli ulcer. Intriguingly, patients with …

Nontuberculous mycobacteria (NTM) are a diverse group of organisms that are ubiquitous in
the environment, and the incidence of cutaneous infections due to NTM has been steadily …