This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Dysfunction of the endothelial lining of lesion-prone areas of the arterial vasculature is an
important contributor to the pathobiology of atherosclerotic cardiovascular disease …

Atherosclerosis, the chronic accumulation of cholesterol-rich plaque within arteries, is
associated with a broad spectrum of cardiovascular diseases including myocardial …

The focal nature of atherosclerotic lesions suggests an important role of local hemodynamic
environment. Recent studies have demonstrated significant roles of Yes-associated protein …

Atherosclerosis is the primary underlying cause of myocardial infarction, ischemic stroke,
and peripheral artery disease. The disease preferentially occurs in arterial regions exposed …

Background Endothelial cell (EC) dysfunctions, including turnover enrichment, gap junction
disruption, inflammation, and oxidation, play vital roles in the initiation of vascular disorders …

Background and Purpose—Endovascular thrombectomy has shown promise for the
treatment of acute strokes resulting from large-vessel occlusion. Reperfusion-related injury …

Atherosclerosis is characterised by the accumulation of lipid-laden macrophages in
atherosclerotic lesions and occurs preferentially at arterial branching points, which are …

Background and Purpose—Progression of asymptomatic carotid artery stenosis (ACAS) in
patients with> 50% luminal narrowing is considered a potential risk factor for ischemic …

Blood flow at arterial bifurcations and curvatures is naturally disturbed. Endothelial cells
(ECs) fail to adapt to disturbed flow, which transcriptionally direct ECs toward a maladapted …