In recent years, pulmonary imaging has seen enormous progress, with the introduction,
validation and implementation of new hardware and software. There is a general trend from …

The promise of genetic therapies has turned into reality in recent years, with new first-line
treatments for fatal diseases now available to patients. The development and testing of …

The aim of this study was to assess the association between regional tidal volume (Vt),
regional functional residual capacity (FRC), and the expression of genes linked with …

We have developed an x-ray imaging system for in vivo four-dimensional computed
tomography (4DCT) of small animals for pre-clinical lung investigations. Our customized …

Detailed information on the distribution of airway diameters during bronchoconstriction in
situ is required to understand the regional response of the lungs. Imaging studies using …

Blood vessels form intricate networks in 3-dimensional space. Consequently, it is difficult to
visually appreciate how vascular networks interact and behave by observing the surface of a …

Increased dead space is an important prognostic marker in early acute respiratory distress
syndrome (ARDS) that correlates with mortality. The cause of increased dead space in …

Pulmonary hypertension is a chronic vascular disease characterized by pulmonary
vasoconstriction and pulmonary arterial remodeling. Pulmonary arterial remodeling is …

Imaging in small animal models of lung disease is challenging, as existing technologies are
limited either by resolution or by the terminal nature of the imaging approach. Here, we …

Noninvasive imaging of the murine pulmonary vasculature is challenging due to the small
size of the animal, limits of resolution of the imaging technology, terminal nature of the …