Polymeric in situ forming depots for long-acting drug delivery systems

AK Pandya, LK Vora, C Umeyor, D Surve… - Advanced Drug Delivery …, 2023 - Elsevier
Polymeric in situ forming depots have emerged as highly promising drug delivery systems
for long-acting applications. Their effectiveness is attributed to essential characteristics such …

Recent advances of smart materials for ocular drug delivery

X Wang, F Luan, H Yue, C Song, S Wang… - Advanced drug delivery …, 2023 - Elsevier
Owing to the variety and complexity of ocular diseases and the natural ocular barriers, drug
therapy for ocular diseases has significant limitations, such as poor drug targeting to the site …

Biodegradable polymer-based drug-delivery Systems for Ocular Diseases

TH Tsung, YC Tsai, HP Lee, YH Chen… - International Journal of …, 2023 - mdpi.com
Ocular drug delivery is a challenging field due to the unique anatomical and physiological
barriers of the eye. Biodegradable polymers have emerged as promising tools for efficient …

Updates on biodegradable formulations for ocular drug delivery

TH Tsung, YH Chen, DW Lu - Pharmaceutics, 2023 - mdpi.com
The complex nature of the ocular drug delivery barrier presents a significant challenge to the
effective administration of drugs, resulting in poor therapeutic outcomes. To address this …

Ophthalmic nano-bioconjugates: critical challenges and technological advances

SN Sanap, AC Bisen, S Agrawal, A Kedar… - Therapeutic …, 2023 - Taylor & Francis
Ophthalmic disease can cause permanent loss of vision and blindness. Easy-to-administer
topical and systemic treatments are preferred for treating sight-threatening disorders. Typical …

Ag/Cu nanoparticles-loaded glycocalyx biomimetic corneal bandage lenses for combatting bacterial keratitis

Y Dai, J Zhang, S Zhang, L Li, C Qu, J Chen… - Journal of Controlled …, 2024 - Elsevier
Bacterial keratitis is a major cause of blindness, hindered by the rising threat of antibiotic
resistance. Although corneal bandage lenses (CBLs) are widely utilized in ophthalmic …

Development, evaluation and recent progress of ocular in situ gelling drug delivery vehicle based on poloxamer 407

M Dewan, A Adhikari, R Jana… - Journal of Drug Delivery …, 2023 - Elsevier
The fabrication of an effective in situ gelling ophthalmic drug delivery vehicle is recently
received enormous interest to overcome the demerits of conventional ocular solutions and …

Current advances in nano-based and polymeric stimuli-responsive drug delivery targeting the ocular microenvironment: a review and envisaged future perspectives

SBK Dludla, LT Mashabela, B Ng'andwe, PA Makoni… - Polymers, 2022 - mdpi.com
Optimal vision remains one of the most essential elements of the sensory system
continuously threatened by many ocular pathologies. Various pharmacological agents …

Self‐Implantable Core–Shell Microneedle Patch for Long‐Acting Treatment of Keratitis via Programmed Drug Release

X Jiang, Y Jin, Y Zeng, P Shi, W Li - Small, 2024 - Wiley Online Library
Bacteria‐induced keratitis is a major cause of corneal blindness in both developed and
developing countries. Instillation of antibiotic eyedrops is the most common management of …

Ophthalmic bimatoprost-loaded niosomal in situ gel: preparation, optimization, and in vivo pharmacodynamics study

MF Aldawsari, EH Moglad, HF Alotaibi, HM Alkahtani… - Polymers, 2023 - mdpi.com
This study aimed at formulating the antiglaucoma agent, Bimatoprost (BMT), into niosomal in
situ gel (BMT-ISG) for ocular delivery. Niosomes containing cholesterol/span 60 entrapping …