Objective: Parkinson's disease (PD) is a progressive neurological disorder characterised by
a large number of motor and non-motor features that can impact on function to a variable …

Pathophysiology The establishment of a model of parkinsonism through the administration
of MPTP to nonhuman primates has provided important insights into new therapeutic …

The correct diagnosis of Parkinson's disease is important for prognostic and therapeutic
reasons and is essential for clinical research. Investigations of the diagnostic accuracy for …

OBJECTIVE: Since all antipsychotics block dopamine D2 receptors, the authors investigated
how well D2 receptor occupancy in vivo predicts clinical response, extrapyramidal side …

Molecular imaging is an attractive technology widely used in clinical practice that greatly
enhances our understanding of the pathophysiology and treatment in central nervous …

Background Serial dopamine transporter (DAT) imaging in patients with Parkinson's disease
(PD) and other synucleinopathies shows progressive nigrostriatal dopaminergic dysfunction …

ContextPramipexole and levodopa are effective medications to treat motor symptoms of
early Parkinson disease (PD). In vitro and animal studies suggest that pramipexole may …

Early detection of neurodegenerative disorders would provide clues to the underlying
pathobiology of these diseases and would enable more effective diagnosis and treatment of …

These guidelines summarize the current views of the European Association of Nuclear
Medicine Neuroimaging Committee (ENC). The aim of the guidelines is to assist nuclear …

OBJECTIVES: The main neuropathological feature in Parkinson's disease is a severe
degeneration of the dopaminergic neurons in the substantia nigra resulting in a loss of …