The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide
range of incurable diseases. Recent rapid advances in biotechnology and molecular …

Prokaryotes have developed an adaptive immune system called Clustered regularly
interspaced short palindromic repeats (CRISPR) to combat attacks by foreign mobile genetic …

Patient derived anti-CD19 chimeric antigen receptor-T (CAR-T) cells are a powerful tool in
achieving a complete remission in a range of B-cell malignancies, most notably B-acute …

We present an overview of clinical trials involving gene editing using clustered interspaced
short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (Cas9), transcription …

Over the past decades, adoptive transfer of T cells has revolutionized cancer
immunotherapy. In particular, T-cell receptor (TCR) engineering of T cells has marked …

Gene editing can be used to overcome allo-recognition, which otherwise limits allogeneic T
cell therapies. Initial proof-of-concept applications have included generation of such" …

The CRISPR/Cas9 system has recently been shown to facilitate high levels of precise
genome editing using adeno-associated viral (AAV) vectors to serve as donor template DNA …

T cell receptor (TCR)-based adoptive T cell therapies (ACT) hold great promise for the
treatment of cancer, as TCRs can cover a broad range of target antigens. Here we …

The idea of mRNA therapy had been conceived for decades before it came into reality
during the Covid-19 pandemic. The mRNA vaccine emerges as a powerful and general tool …

Genome editing tools have already revolutionized biomedical research and are also
expected to have an important impact in the clinic. However, their extensive use in research …