Severe malaria has a high mortality rate (15–20%) despite treatment with effective
antimalarial drugs. Adjunctive therapies for severe malaria that target the underlying disease …

Plasmodium falciparum causes the most severe form of malaria and is responsible for
essentially all malaria-related deaths. The accumulation in various tissues of erythrocytes …

The factors determining disease severity in malaria are complex and include host
polymorphisms, acquired immunity and parasite virulence. Studies in Africa have shown that …

Variant surface antigens play an important role in Plasmodium falciparum malaria
pathogenesis and in immune evasion by the parasite. Although most work to date has …

After a successful invasion, malaria parasite Plasmodium falciparum extensively remodels
the infected erythrocyte cellular architecture, conferring cytoadhesive properties to the …

Severe Plasmodium falciparum malaria is characterized by excessive sequestration of
infected and uninfected erythrocytes in the microvasculature of the affected organ. Rosetting …

Cerebral malaria (CM) is a deadly complication of Plasmodium falciparum infection, but
specific interactions involved in cerebral homing of infected erythrocytes (IEs) are poorly …

The particular virulence of Plasmodium falciparum compared with the other malaria species
which naturally infect humans is thought to be due to the way in which the parasite modifies …

OBJECTIVE: To identify the possible antiplasmodial compounds from leaf, stem, root and
flower extracts of Ocimum canum (O. canum), Ocimum sanctum (O. sanctum) and Ocimum …

Plasmodium spp. parasites that cause malaria disease remain a significant global-health
burden. With the spread of parasites resistant to artemisinin combination therapies in …