Genetic and biological hallmarks of colorectal cancer

J Li, X Ma, D Chakravarti, S Shalapour… - Genes & …, 2021 - genesdev.cshlp.org
Colorectal cancer has served as a genetic and biological paradigm for the evolution of solid
tumors, and these insights have illuminated early detection, risk stratification, prevention …

Lymphatic vessels in cancer

LC Dieterich, C Tacconi, L Ducoli… - Physiological …, 2022 - journals.physiology.org
The lymphatic system, composed of initial and collecting lymphatic vessels as well as lymph
nodes that are present in almost every tissue of the human body, acts as an essential …

The extracellular matrix: its composition, function, remodeling, and role in tumorigenesis

K Dzobo, C Dandara - Biomimetics, 2023 - mdpi.com
The extracellular matrix (ECM) is a ubiquitous member of the body and is key to the
maintenance of tissue and organ integrity. Initially thought to be a bystander in many cellular …

Intestinal lymphatic vasculature: structure, mechanisms and functions

J Bernier-Latmani, TV Petrova - Nature reviews Gastroenterology & …, 2017 - nature.com
The mammalian intestine is richly supplied with lymphatic vasculature, which has functions
ranging from maintenance of interstitial fluid balance to transport of antigens, antigen …

Long noncoding RNA BLACAT2 promotes bladder cancer–associated lymphangiogenesis and lymphatic metastasis

W He, G Zhong, N Jiang, B Wang, X Fan… - The Journal of …, 2018 - Am Soc Clin Investig
The prognosis for bladder cancer patients with lymph node (LN) metastasis is dismal and
only minimally improved by current treatment modalities. Elucidation of the molecular …

Platelet-derived growth factor-D enables liver myofibroblasts to promote tumor lymphangiogenesis in cholangiocarcinoma

M Cadamuro, S Brivio, J Mertens, M Vismara… - Journal of …, 2019 - Elsevier
Background & Aims In cholangiocarcinoma, early metastatic spread via lymphatic vessels
often precludes curative therapies. Cholangiocarcinoma invasiveness is fostered by an …

Growth and immune evasion of lymph node metastasis

D Jones, ER Pereira, TP Padera - Frontiers in oncology, 2018 - frontiersin.org
Cancer patients with lymph node (LN) metastases have a worse prognosis than those
without nodal disease. However, why LN metastases correlate with reduced patient survival …

Lymphangiocrine signals are required for proper intestinal repair after cytotoxic injury

B Palikuqi, J Rispal, EA Reyes, D Vaka, D Boffelli… - Cell Stem Cell, 2022 - cell.com
The intestinal epithelium undergoes continuous renewal and has an exceptional capacity to
regenerate after injury. Maintenance and proliferation of intestinal stem cells (ISCs) are …

Lymphatic endothelial cell junctions: molecular regulation in physiology and diseases

F Zhang, G Zarkada, S Yi, A Eichmann - Frontiers in physiology, 2020 - frontiersin.org
Lymphatic endothelial cells (LECs) lining lymphatic vessels develop specialized cell-cell
junctions that are crucial for the maintenance of vessel integrity and proper lymphatic …

CRIP1 reshapes the gastric cancer microenvironment to facilitate development of lymphatic metastasis

Z Wu, B Qu, M Yuan, J Liu, C Zhou, M Sun… - Advanced …, 2023 - Wiley Online Library
Lymphangiogenesis in tumors provides an auxiliary route for cancer cell invasion to
drainage lymph nodes, facilitating the development of lymphatic metastasis (LM). However …