Single molecule real-time (SMRT) sequencing comes of age: applications and utilities for medical diagnostics
S Ardui, A Ameur, JR Vermeesch… - Nucleic acids …, 2018 - academic.oup.com
Short read massive parallel sequencing has emerged as a standard diagnostic tool in the
medical setting. However, short read technologies have inherent limitations such as GC …
medical setting. However, short read technologies have inherent limitations such as GC …
Virulence of the zoonotic agent of leptospirosis: still terra incognita?
M Picardeau - Nature Reviews Microbiology, 2017 - nature.com
Pathogenic leptospires are the bacterial agents of leptospirosis, which is an emerging
zoonotic disease that affects animals and humans worldwide. The success of leptospires as …
zoonotic disease that affects animals and humans worldwide. The success of leptospires as …
Genus-wide Leptospira core genome multilocus sequence typing for strain taxonomy and global surveillance
J Guglielmini, P Bourhy, O Schiettekatte… - PLoS neglected …, 2019 - journals.plos.org
Leptospira is a highly heterogeneous bacterial genus that can be divided into three
evolutionary lineages and> 300 serovars. The causative agents of leptospirosis are …
evolutionary lineages and> 300 serovars. The causative agents of leptospirosis are …
Advantages of genome sequencing by long-read sequencer using SMRT technology in medical area
K Nakano, A Shiroma, M Shimoji, H Tamotsu… - Human cell, 2017 - Springer
PacBio RS II is the first commercialized third-generation DNA sequencer able to sequence a
single molecule DNA in real-time without amplification. PacBio RS II's sequencing …
single molecule DNA in real-time without amplification. PacBio RS II's sequencing …
Leptospira spp., a genus in the stage of diversity and genomic data expansion
K Caimi, P Ruybal - Infection, Genetics and Evolution, 2020 - Elsevier
Leptospirosis is a widespread global zoonotic bacterial disease with a noteworthy human-
animal-ecosystem interface. The disease presents different clinical manifestations and a …
animal-ecosystem interface. The disease presents different clinical manifestations and a …
4-Methylcytosine DNA modification is critical for global epigenetic regulation and virulence in the human pathogen Leptospira interrogans
RA Gaultney, AT Vincent, C Lorioux… - Nucleic Acids …, 2020 - academic.oup.com
In bacteria, DNA methylation can be facilitated by 'orphan'DNA methyltransferases lacking
cognate restriction endonucleases, but whether and how these enzymes control key cellular …
cognate restriction endonucleases, but whether and how these enzymes control key cellular …
Characterizing interactions of Leptospira interrogans with proximal renal tubule epithelial cells
T Yamaguchi, N Higa, N Okura, A Matsumoto… - BMC microbiology, 2018 - Springer
Background Leptospira interrogans is a pathogenic, spirochetal bacterium that is
responsible for leptospirosis, an emerging worldwide zoonosis. Leptospires colonize the …
responsible for leptospirosis, an emerging worldwide zoonosis. Leptospires colonize the …
Leptospira and Leptospirosis
M Picardeau - Leptospira spp. Methods and Protocols, 2020 - Springer
Leptospira spp. are morphologically and phylogenetically unique bacteria that are
ubiquitous in the environment. Pathogenic species are the agents of leptospirosis, an …
ubiquitous in the environment. Pathogenic species are the agents of leptospirosis, an …
Analysis of human clinical and environmental Leptospira to elucidate the eco-epidemiology of leptospirosis in Yaeyama, subtropical Japan
Y Sato, I Hermawan, T Kakita, S Okano… - PLoS Neglected …, 2022 - journals.plos.org
Background Leptospirosis, a zoonosis caused by species in the spirochete genus
Leptospira, is endemic to the Yaeyama region in Okinawa, subtropical Japan. Species of the …
Leptospira, is endemic to the Yaeyama region in Okinawa, subtropical Japan. Species of the …
An extracellular Leptospira interrogans leucine‐rich repeat protein binds human E‐ and VE‐cadherins
Pathogenic Leptospira bacteria are the causative agents of leptospirosis, a zoonotic disease
affecting animals and humans worldwide. These pathogenic species have the ability to …
affecting animals and humans worldwide. These pathogenic species have the ability to …