Recent advances in optical tissue clearing and three-dimensional (3D) fluorescence
microscopy have enabled high resolution in situ imaging of intact tissues. Using simply …

Axially swept light-sheet microscopy (ASLM) is an effective method of generating a uniform
light sheet across a large field of view (FOV). However, current ASLM designs are more …

Advances in three-dimensional microscopy and tissue clearing are enabling whole-organ
imaging with single-cell resolution. Fast and reliable image processing tools are needed to …

We report a single‐step optical clearing method that is compatible with RNA fluorescence in
situ hybridization (FISH) imaging. We previously demonstrated microscopy imaging with …

While major coronary artery development and pathologies affecting them have been
extensively studied, understanding the development and organization of the coronary …

We propose digital labeling, a method for automated, three-dimensional segmentation of
blood vessels without vascular contrast agents. Our deep learning approach greatly …

Congenital heart disease (CHD) is the most common birth defect and the leading cause of
infant death. The mechanisms behind CHD have been the focus of many studies but our …