Background Depression is one of the most debilitating and severe psychiatric disorders and
a serious public health concern. Currently, many treatments are indicated for depression …

Emerging from the depths of evolution, pituitary adenylate cyclase-activating polypeptide
(PACAP) and its receptors (ie, PAC1, VPAC1, VPAC2) are present in multicellular organisms …

Vasoactive intestinal peptide (VIP) is an important modulatory peptide throughout the CNS
acting as a neurotransmitter, neurotrophic or neuroprotective factor. In the hippocampus, a …

Synaptic plasticity is a cellular process involved in learning and memory whose alteration in
its two main forms (Long Term Depression (LTD) and Long Term Potentiation (LTP)), is …

Long‐term potentiation (LTP) is a highly studied cellular process, yet determining the
transduction and gamma aminobutyric acid (GABAergic) pathways that are the essential …

Cognition and other higher brain functions are known to be intricately associated with the
capacity of neural circuits to undergo structural reorganization. Structural remodelling of …

In mesial temporal lobe epilepsy (MTLE), seizures typically arise in the hippocampus or
other mesial temporal lobe structures. The aetiology of MTLE epileptogenesis in still …

Simple Summary Regulation of synaptic plasticity through control of disinhibition is an
important process in the prevention of excessive plasticity in both physiological and …

The enteric nervous system (ENS) situated within the gastrointestinal tract comprises an
intricate network of neurons and glia which together regulate intestinal function. The exact …

Memory formation relies on experience-dependent changes in synaptic strength such as
long-term potentiation (LTP) or long-term depression (LTD) of synaptic activity, that in turn …