[HTML][HTML] NETosis and neutrophil extracellular traps in COVID-19: immunothrombosis and beyond

Y Zhu, X Chen, X Liu - Frontiers in Immunology, 2022 - frontiersin.org
Infection with SARS-CoV-2, the causative agent of the Coronavirus disease 2019 (COVID-
19) pandemic, causes respiratory problems and multifaceted organ dysfunction. A crucial …

Neutrophil extracellular traps: from physiology to pathology

A Hidalgo, P Libby, O Soehnlein… - Cardiovascular …, 2022 - academic.oup.com
At the frontline of the host defence response, neutrophil antimicrobial functions have
adapted to combat infections and injuries of different origins and magnitude. The release of …

Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19

AJ Wilk, MJ Lee, B Wei, B Parks, R Pi… - Journal of Experimental …, 2021 - rupress.org
Our understanding of protective versus pathological immune responses to SARS-CoV-2, the
virus that causes coronavirus disease 2019 (COVID-19), is limited by inadequate profiling of …

[HTML][HTML] Multivalent glycosystems for human lectins

M Martínez-Bailén, J Rojo… - Chemical Society …, 2023 - pubs.rsc.org
Human lectins are involved in a wide variety of biological processes, both physiological and
pathological, which have attracted the interest of the scientific community working in the …

[HTML][HTML] Siglec ligands

A Gonzalez-Gil, RL Schnaar - Cells, 2021 - mdpi.com
A dense and diverse array of glycans on glycoproteins and glycolipids decorate all cell
surfaces. In vertebrates, many of these carry sialic acid, in a variety of linkages and glycan …

Therapeutic poly (amino acid) s as drug carriers for cancer therapy

H Hu, Z Zhang, Y Fang, L Chen, J Wu - Chinese Chemical Letters, 2023 - Elsevier
As one of the top global health problems, the effective treatment of cancer is one of the most
urgent clinical challenges. Currently, the main treatments for cancer include surgery …

[HTML][HTML] Mechanism for the attenuation of neutrophil and complement hyperactivity by MSC exosomes

JT Loh, B Zhang, JKH Teo, RC Lai, ABH Choo, KP Lam… - Cytotherapy, 2022 - Elsevier
Complements and neutrophils are two key players of the innate immune system that are
widely implicated as drivers of severe COVID-19 pathogenesis, as evident by the direct …

Design of Glycopolymers for Controlling the Interactions with Lectins

M Nagao, H Matsumoto, Y Miura - Chemistry–An Asian Journal, 2023 - Wiley Online Library
Carbohydrates are involved in life activities through the interactions with their corresponding
proteins (lectins). Pathogen infection and the regulation of cell activity are controlled by the …

[HTML][HTML] Oxidative stress and ROS-mediated cellular events in RSV infection: potential protective roles of antioxidants

X Yang, X Liu, Y Nie, F Zhan, B Zhu - Virology Journal, 2023 - Springer
Respiratory syncytial virus (RSV), a member of the Pneumoviridae family, can cause severe
acute lower respiratory tract infection in infants, young children, immunocompromised …

The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis

X He, X Zhang, B Wu, J Deng, Y Zhang, A Zhu… - Nature …, 2024 - nature.com
The development of a vaccine specific to severe acute respiratory syndrome coronavirus 2
Omicron has been hampered due to its low immunogenicity. Here, using reverse …