Since the discovery of the phosphorylation of the 40S ribosomal protein S6 (rpS6) about four
decades ago, much effort has been made to uncover the molecular mechanisms underlying …

Gilles de la Tourette syndrome (GTS) is a childhood-onset neurodevelopmental disorder
that is characterized by several motor and phonic tics. Tics usually develop before 10 years …

There is accumulating evidence that immune dysregulation contributes to the
pathophysiology of obsessive‐compulsive disorder (OCD), Tourette syndrome, and …

Loss-of-function mutations of the gene Cul3 have been identified as a risk factor for autism-
spectrum disorder (ASD), but the pathogenic mechanisms are not well understood …

The neuromodulator histamine is released throughout the brain during periods of
wakefulness. Combined with an abundant expression of histamine receptors, this suggests …

Background Interneuronal pathology is implicated in many neuropsychiatric disorders,
including autism spectrum disorder (ASD) and Tourette syndrome (TS). Interneurons of the …

Microglia mediate neuroinflammation and regulate brain development and homeostasis.
Microglial abnormalities are implicated in a range of neuropsychiatric pathology, including …

The potential contributions of dysregulation of the brain's histaminergic modulatory system to
neuropsychiatric disease, and the potential of histamine-targeting medications as …

Gilles de la Tourette Syndrome (TS) is a childhood-onset neurodevelopmental disorder that
is characterized by multiple motor and phonic tics. It has a complex etiology with multiple …

Tic disorders affect~ 5% of the population and are frequently comorbid with obsessive-
compulsive disorder, autism, and attention deficit disorder. Histamine dysregulation has …